Talk:DNA mismatch repair

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According to Nature [DNA Replication and Causes of Mutation By: Leslie A. Pray, Ph.D. © 2008 Nature Education Citation: Pray, L. (2008) DNA replication and causes of mutation. Nature Education 1(1)], tautomerization is not the source of mismatches, but it is wobble base pairing.153.90.184.67 (talk) 21:17, 13 June 2012 (UTC)[reply]

The nicks are there because of the Okazaki fragments added on chain not affected by DNA polymerase 16:03, 28 September 2011 (UTC)

Does anyone know for sure whether it is DNA Polymerase III (as was stated in this article) or DNA Polymerase I that fills the gap from the excised strand? I believe it's DNA Pol I that does this kind of short sequence synthesis.

It's DNA Polymerase III Matt Peacock 11:35, 6 May 2006 (UTC)[reply]

I'm about to take a genetics final, and I can say for sure that DNA polymerase I does the 3 to 5 endonuclease activity to remove the primers of Okazaki fragments and DNA polymerase III then fills in this gap —Preceding unsigned comment added by 131.212.43.238 (talk) 19:56, 20 December 2007 (UTC)[reply]

It would be good to include a section or sub-section that discussed the mut proteins in detail, for example crystal structure and homologues etc. Also to discuss the three models; the translocation model, the sliding clamp model and the transactivation model. Finally if someone could add 'very short patch repair' that would be good. Matt Peacock 21:27, 6 May 2006 (UTC)[reply]

Added some info to the MutL section, see the ref (Mechanic et al, 2000) for more on UvrD and MutL. It's actually a pretty good paper, and some of the references they give could be used to further expand the page. It also talks about that "sliding clamp" model that UvrD may hypothetically use to increase processivity. Mechanic et al says that's bogus, but you might be talking about a different sliding clamp. That said, the paper's from 2000, so there might be something more recent which invalidates the entire thing.OParker 23:34, 17 May 2006 (UTC)[reply]

Good find, I've edited it a bit but I think it's definitely worth putting it in the main section of the artcile. Matt Peacock 21:44, 22 May 2006 (UTC)[reply]

Can anyone write just a bit more about MMR in mammalian cells?... Tnx in advance 77.133.43.210 17:22, 14 July 2007 (UTC)[reply]