Talk:Monoamine oxidase

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I believe the Caspi study has been hyper-represented in this article, and that the importance of MAO in the degradation of neurotransmitters has not been written up. Can we restore the balance somehow (which will include reducing the long write-up on one study)? JFW | T@lk 17:28, 12 Aug 2004 (UTC)

I agree, JFW. I've submitted the page for attention. Axl 18:41, 3 Dec 2004 (UTC)

There is also no mention of MAO-B, which does the same for Dopamine and a whole range of "lesser" monoamines. The selective, irreversible MAO-B inhibitor Selegelin is considered an anti-Parkinson drug, and works primarily by decreasing reuptake and decomposition of dopamine, and secondarily by having levo-methamphetamine as the metabolite. It would probably be a very interesting candidate for use in depressive disorders, either as monotherapy, or as an augmentor to e.g. Moclobemid. The now-illegal Amineptin showed great promise as a fast-acting, effective antidepressant due to its action on the dopamine system. It was eventually outlawed for these exact same properties, that in a healthy person can produce euphoria. - Unregistered.

Someone has now added information about MAO-B. You make some interesting comments about the MAO inhibitors, but they would be better placed in the article monoamine oxidase inhibitor. Axl 19:45, 9 Mar 2005 (UTC)

"Monoamine oxidase contains the covalently-bound cofactor FAD."

Perhaps a minor issue, but correct me if im wrong, but in Med School, we were taught that FAD (as an organic substance) is a co-enzyme as it is a substrate involved within the reaction. Am I mistaken?--220.237.56.163 11:44, 23 October 2006 (UTC)[reply]

Are both forms of MAO found only on the surfaces of mitochondria? A book I was reading mentioned MAO being found there but didn't differentiate between A and B forms (the book was printed in 1984). If mitochondria have their own genetic material, does this mean that the genes for one or both MAOs are stored in the mitochondria and not in the nucleus of the cell?--Eloil 00:31, 28 February 2007 (UTC)[reply]

Just read in the article that both forms are coded for on the x chromosome. --Eloil 00:39, 28 February 2007 (UTC)[reply]

i can't believ that criminality is in the list of disorders which affect those with irregular MOAs. i mean come on! show me at least one paper that says this. what about the link to norrie disease? and the cases of those with a complete absence of MOA due to a deleation of Xp21-p11. a list of somatic growth failure; abnormal sexual maturation; autonmic nervous system dysfunction and others would be better suitable than vague thing such as social phobias... when i find a reference to use i will edit. anyone not agree? —The preceding