Talk:Pyrimidine dimer
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 | The contents of the Direct DNA damage page were merged into Pyrimidine dimer on 4 September 2022. For the contribution history and old versions of the redirected page, please see its history; for the discussion at that location, see its talk page. |
Proposed merger
I'm proposing that
- Okay, I've set up a draft of the proposed new Pyrimidine Dimer page here: Thymine dimerpage with a redirect to that one. If anyone cares, please say so soon.
- Sounds good. I will rescue the highly chemical bit abuot cyclobutanes. Thymine dimer is not very impressive as it stands, so your work is a real improvement.--Smokefoot (talk) 16:23, 16 August 2009 (UTC)]
 | This article may be too technical for most readers to understand. (September 2010) |
- Although this article is about a technical subject, the lead should be made easier to understand. For example, the word “translesion,” although correct, is not in the dictionary. Bwrs (talk) Bwrs (talk) 03:34, 1 December 2009 (UTC)
References
- PMID 16954188.)
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link - PMID 1946433.)
{{cite journal}}: Explicit use of et al. in:|author=(help); Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link
Not 6-4 and left handed DNA
In the figure illustrating the types of dimers, 6-4 photoproduct is shown incorrectly. What is shown is a so-called "spore photoproduct" (http://www.photobiology.com/photoiupac2000/nichol/index.htm). The structure of 6-4 is quite different (http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=cmed&part=A3935, Fig. 15.2) —Preceding unsigned comment added by 89.251.107.24 (talk) 11:44, 12 June 2010 (UTC)
- The SP product is okay according to 2006 paper by Buis et al ... doi:10.1074/jbc.M603931200. Your ref (http://www.photobiology.com/photoiupac2000/nichol/index.htm) gets its structure for Figure 15.2 from Taylor et al J Am Chem Soc. 1987; 109: 2834–2835, which might be obsolete. Medical sources occasionally are way behind on their chemistry.--Smokefoot (talk) 01:24, 16 November 2010 (UTC)
The image 'DNA_UV_mutation.svg' shows a left-handed DNA, it should be a right handed DNA. This a fundamental mistake.
Assessment comment
The comment(s) below were originally left at Talk:Pyrimidine dimer/Comments, and are posted here for posterity. Following several discussions in past years, these subpages are now deprecated. The comments may be irrelevant or outdated; if so, please feel free to remove this section.
| The final diagram is in error. The ring double bonds in the thiamines have remained, despite the formation of the dimer. I am not expert enough to know the exact arrangement, but do know that 5-bonnded carbon is wrong. I agree, there should not be a double bond in the ring of the two thymine dimers anymore. Someone needs to edit the diagram. —Preceding unsigned comment added by 128.220.159.20 (talk) 17:17, 10 December 2007 (UTC) |
Substituted at 21:56, 26 June 2016 (UTC)
Perhaps the citation needed for most melanomas deriving from pyrimidine dimers
Hart et al. (1977) reported that thyroid tumors that developed from transplanted UV-C-irradiated thyroid cells were highly photoreactivable in the small tropical fish Poecilia formosa showing that pyrimidine dimers can induce tumors. R.B. Setlow et al. (1989) later found that PR treatment of a platyfish-swordtail hybrid (Xiphophorus) reduced the incidence of UV-B-induced melanoma to background levels, and Ley et al. (1989) found PR of melanoma induction in the skin of M. domestica. These results showed that CPDs produced by either UV-B or UV-C can act as complete carcinogens for melanoma induction. Cook & McGrath (1967) had earlier failed to find PR activity in skin of the mouse or rabbit.
http://photobiology.info/Jagger.html — Preceding unsigned comment added by 184.66.250.169 (talk) 00:11, 5 April 2017 (UTC)
Proposed merge of Direct DNA damage into Pyrimidine dimer
Same topic, more focused on human skin, less well-written Artoria2e5 🌉 12:39, 17 January 2021 (UTC)
Wiki Education assignment: History of Science to Newton
This article was the subject of a Wiki Education Foundation-supported course assignment, between 17 January 2023 and 11 May 2023. Further details are available on the course page. Student editor(s): BigPoppa1923 (article contribs).
— Assignment last updated by BigPoppa1923 (talk) 02:13, 18 April 2023 (UTC)