Tardive psychosis

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Tardive psychosis is a term for a hypothetical form of psychosis caused by long-term use of neuroleptics. It was first proposed in 1978 but was questioned by the late 1980s.[1][2] It was hypothesized that psychosis could arise as neuroleptic medication become decreasingly effective, requiring higher doses, or when not responding to higher doses.[3]

Evaluation suggests that "tardive psychosis" is better described as a combination of "several different and not necessarily correlated phenomena related to neuroleptic treatment of schizophrenia."[2]

Some articles equated tardive psychosis to

supersensitivity psychosis. However, descriptions of symptoms of the latter do not match the former. Specific supersensitivity psychosis articles focus on psychotic episodes in the wake of psychotic medication withdrawal associated with Clozapine, rather than on medication resistance.[4] A hypothetical condition related to tardive psychosis, tardive dysmentia, has also been questioned.[5]

Description

The theoretical tardive psychosis is distinct from

antipsychotics by the depletion of dopamine and related to the known side effect caused by their long-term use, tardive dyskinesia.[citation needed
]

In addition to dopaminergic upregulation in the

mesocortical tracts, leading to a worsening of psychosis beyond the original level. This phenomenon has been called 'tardive psychosis' or 'supersensitivity psychosis'.[6]

Tardive psychosis was researched in 1978 and 1989, and sporadic research continues. Some studies have found it to be associated with psychotic depression and potentially, dissociation. For people with any tardive conditions

NMDA receptor modulators (glutamate antagonists) in not creating tardive dyskinesia will not create this condition.[citation needed
]

See also

References

  1. ISSN 0002-953X
    .
  2. ^
    PMID 2894699
    .
  3. PMID 6101522.{{cite journal}}: CS1 maint: multiple names: authors list (link
    )
  4. ^ Swartz, Conrad M. (2004-10-01). "Antipsychotic Psychosis". Psychiatric Times. 21 (12): 17.
  5. PMID 6135252
    .
  6. PMID 15465996
    .
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