Thiosemicarbazone
A thiosemicarbazone is an
organosulfur compound with the formula H2NC(S)NHN=CR2. Many variations exist, including those where some or all of the NH centers are substituted by organic groups. Thiosemicarbazones are usually produced by condensation of a thiosemicarbazide with an aldehyde or ketone
:
- H2NC(S)NHNH2 + O=CR2 → H2NC(S)NHN=CR2 + H2O
In terms of their chemical structures, the CSN3 core atoms are coplanar.[1]
Occurrence and applications
Some thiosemicarbazones have medicinal properties, e.g. the antiviral
coordination chemistry.[2] The affinity of thiosemicarbazones for metal ions is exploited in controlling iron overload.[3]