Transactivation

Source: Wikipedia, the free encyclopedia.

In the context of gene regulation: transactivation is the increased rate of gene expression triggered either by biological processes or by artificial means, through the expression of an intermediate transactivator protein.

In the context of receptor signaling, transactivation occurs when one or more receptors activate yet another;

signaling cascades or the activation of G protein–coupled receptor hetero-oligomer subunits, among other mechanisms.[1]

Natural transactivation

Transactivation can be triggered either by endogenous cellular or viral proteins, also called transactivators. These protein factors

transcription factors, leads to uncontrolled proliferation of T-cells and hence lymphoma
.

Artificial transactivation

Artificial transactivation of a gene is achieved by inserting it into the genome at the appropriate area as transactivator gene adjoined to special promoter regions of

promoter region of a gene, the transcription factor causes that gene to be expressed. The expression of one transactivator gene can activate multiple genes, as long as they have the same, specific promoter region attached. Because the expression of the transactivator gene can be controlled, transactivation can be used to turn genes on and off. If this specific promoter region is also attached to a reporter gene
, we can measure when the transactivator is being expressed.

See also

References

  1. ^ a b "receptor transactivation". EMBL. GO Consortium. Retrieved 6 April 2015.
  2. PMID 25671228
    . For instance,there are indications that both D1 and D2 receptors can trans-activate the brain-derived neurotrophic factor (BDNF) receptor in neurons (Swift et al., 2011). These two dopamine receptors can also regulate calcium channels through a direct protein–protein interaction in vivo (Kisilevsky and Zamponi, 2008; Kisilevsky et al., 2008). Direct interaction of D1 and D2 receptors and Na+-K+-ATPase has also been demonstrated (Hazelwood et al., 2008; Blom et al., 2012).

External links
Retrieved from "https://en.wikipedia.org/w/index.php?title=Transactivation&oldid=1003977356"