Transplacental carcinogenesis
carcinogens. Specifically, these changes are identified as malignant by virtue of their metastatic potential.[1]
Transplacental transfer
The link between a pregnant mother and the fetus is such that "at all sites of direct cell-to-cell contact, maternal tissues (
differentiation. The vital balance of cellular activity is disrupted. "The association of in utero exposure to such carcinogens and the subsequent development of cancer has been reported for all childhood cancers combined and particularly for childhood acute lymphoblastic leukemia, lymphoma, and brain tumors."[3]
Fetal cell sensitivity
Fetal cells are most sensitive to carcinogens during the early stages of
differentiation taking place.[6] Notably, tumors are arrived at via proliferating cells. In the event that proliferating cells become uncontrolled, by any measure, this mutated activity would certainly be characteristic of an increased risk in one's chances of developing cancer
.
References
- ISBN 978-0-8385-1535-8.[page needed]
- ^ ISBN 978-0-8385-9634-0.[page needed]
- PMID 1822074.
- ^ PMID 10354502.
- PMID 18383130.
- PMID 2133106.
Further reading
- Magee PN (October 1975). "Transplacental carcinogenesis". Proc. R. Soc. Med. 68 (10): 655–7. PMID 1208519.