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Testing for INaP article
The persistent sodium current (INaP) is a form of sub-threshold, biological
voltage-gated sodium channels found in several central neurons[1]. INaP has been implicated in neuronal excitability, epilepsy, and neuropathic pain[2][3][4]
.
Biophysics
Persistent sodium current generation is hypothesized to occur by the incomplete inactivation of the voltage-gated sodium channel, where the channel becomes constitutively active and conducts sodium, creating a "persistently active" inward sodium current.