User:Mohammed Khimani/sandbox

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**Image is already on the wikipedia page- it is not included in my sandbox**

SPI1 gene

In humans the SPI1 gene is located on chromosome 11, specifically on the p arm of the

lymphoid progenitor cells to initiate differentiation of the progenitor cells to mature immune system cells [2]. Some diseases associated with the SPI1 gene are Inflammatory Diarrhea and Interdigitating Dendritic Cell Sarcoma.

SPI1 has been shown to 

interact
 with:

PU.1 protein function

The PU.1 protein is an

hematopoietic tissues, which are areas where new blood cells form [8]. The ETS domain of the PU.1 protein exhibits a winged helix-turn-helix motif with a loop-helix-loop architecture, and interacts with a 10-base-pair region on duplex DNA [8]. The PU.1 protein has been found to be needed for proper hematopoietic stem cell function and development [2]. Hematopoietic stem cell express PU.1, and its expression is needed for maintenance of the hematopoietic stem cell pool that is kept in the bone marrow [2]
.

Macrophages have the highest levels of PU.1 protein[9]. The PU.1 protein within macrophages control the expression of genes involved in macrophage differentiation and function[9]. The activation of the PU.1 protein allows for myeloid progenitor cells to differentiate and give rise to mature macrophages[9].

Previous research on the PU. 1 protein has found that it can act as an

myeloid and lymphoid lineage cells, thus showing lacking the PU. 1 protein is lethal [9]
.

Acute Myeloid Leukemia (AML)

Acute myeloid leukemia (AML) is a form of blood cancer characterized by no differentiation of white blood cells. The PU.1 transcription factor is known to play a role in AML when mutated. When the gene is mutated is causes a decrease in differentiation of myeloid progenitor cells to white blood cells. Even only a slight reduction in PU.1 levels is enough to cause the AML phenotype.

Reference List

  1. ^ "SPI1 Spi-1 proto-oncogene [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2016-11-20.
  2. ^
    ISSN 1549-4918
    .
  3. PMID 9478924.{{cite journal}}: CS1 maint: unflagged free DOI (link
    )
  4. PMID 10411939
    .
  5. PMID 10022840
    .
  6. PMID 12372320
    .
  7. PMID 23852375
    .
  8. ^
    doi:10.1016/j.biocel.2007.01.026
    .
  9. ^
    ISSN 1078-8956
    .
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