User:ProteinBoxBot/PBB Log Wiki 11-9-2007 A-0

Log file for Protein Box Bot

Log page index: User:ProteinBoxBot/PBB_Log_Index

Protein Status Quick Log - Date: 00:28, 10 November 2007 (UTC)

Proteins without matches (18)

Proteins with a High Potential Match (7)

Created (11)

Manual Inspection (Page not found) (14)

Protein Status Grid - Date: 00:28, 10 November 2007 (UTC)

Vebose Log - Date: 00:28, 10 November 2007 (UTC)

ANP32A

• INFO: Beginning work on ANP32A... {November 9, 2007 4:08:51 PM PST}
• CREATE: Found no pages, creating new page. {November 9, 2007 4:10:23 PM PST}
• CREATED: Created new protein page:
  ANP32A
  {November 9, 2007 4:10:31 PM PST}

ARHGEF7

• INFO: Beginning work on ARHGEF7... {November 9, 2007 4:13:46 PM PST}
• UPLOAD: Added new Image to wiki: File:PBB Protein ARHGEF7 image.jpg {November 9, 2007 4:14:47 PM PST}
• AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 4:15:20 PM PST}

 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image = PBB_Protein_ARHGEF7_image.jpg
 | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1by1.
 | PDB = {{PDB2|1by1}}, {{PDB2|1zsg}}, {{PDB2|2ak5}}, {{PDB2|2df6}}, {{PDB2|2esw}}, {{PDB2|2g6f}}
 | Name = Rho guanine nucleotide exchange factor (GEF) 7
 | HGNCid = 15607
 | Symbol = ARHGEF7
 | AltSymbols =; PAK3; BETA-PIX; COOL1; DKFZp761K1021; KIAA0142; KIAA0412; Nbla10314; P50; P50BP; P85; P85COOL1; P85SPR; PIXB
 | OMIM = 605477
 | ECnumber =  
 | Homologene = 2895
 | MGIid = 1860493
 | GeneAtlas_image1 = PBB_GE_ARHGEF7_202548_s_at_tn.png
 | GeneAtlas_image2 = PBB_GE_ARHGEF7_202547_s_at_tn.png
 | Function = {{GNF_GO|id=GO:0005085 |text = guanyl-nucleotide exchange factor activity}} {{GNF_GO|id=GO:0005089 |text = Rho guanyl-nucleotide exchange factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} 
 | Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} 
 | Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0035023 |text = regulation of Rho protein signal transduction}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8874
    | Hs_Ensembl = ENSG00000102606
    | Hs_RefseqProtein = NP_003890
    | Hs_RefseqmRNA = NM_003899
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 13
    | Hs_GenLoc_start = 110565783
    | Hs_GenLoc_end = 110756081
    | Hs_Uniprot = Q14155
    | Mm_EntrezGene = 54126
    | Mm_Ensembl = ENSMUSG00000031511
    | Mm_RefseqmRNA = NM_017402
    | Mm_RefseqProtein = NP_059098
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 8
    | Mm_GenLoc_start = 11728141
    | Mm_GenLoc_end = 11835191
    | Mm_Uniprot = Q6XPA5
  }}
}}
'''Rho guanine nucleotide exchange factor (GEF) 7''', also known as '''ARHGEF7''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein can induce membrane ruffling. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene, but some of their full-length sequences have not been determined.<ref>{{cite web | title = Entrez Gene: ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8874| accessdate = }}</ref>
}}

==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
}}
{{refend}}

{{protein-stub}}
 

C1QA

• INFO: Beginning work on C1QA... {November 9, 2007 3:51:42 PM PST}
• UPLOAD: Added new Image to wiki: File:PBB Protein C1QA image.jpg {November 9, 2007 3:52:20 PM PST}
• CREATE: Found no pages, creating new page. {November 9, 2007 3:52:28 PM PST}
• CREATED: Created new protein page: C1QA {November 9, 2007 3:52:36 PM PST}

CALM2

• INFO: Beginning work on CALM2... {November 9, 2007 3:52:36 PM PST}
• UPLOAD: Added new Image to wiki: File:PBB Protein CALM2 image.jpg {November 9, 2007 3:52:50 PM PST}
• CREATE: Found no pages, creating new page. {November 9, 2007 3:53:08 PM PST}
• CREATED: Created new protein page: CALM2 {November 9, 2007 3:53:15 PM PST}

CBLB

• INFO: Beginning work on CBLB... {November 9, 2007 3:53:15 PM PST}
• UPLOAD: Added new Image to wiki: File:PBB Protein CBLB image.jpg {November 9, 2007 3:53:56 PM PST}
• CREATE: Found no pages, creating new page. {November 9, 2007 3:54:19 PM PST}
• CREATED: Created new protein page: CBLB {November 9, 2007 3:54:27 PM PST}

CLCN5

• INFO: Beginning work on CLCN5... {November 9, 2007 3:54:27 PM PST}
• UPLOAD: Added new Image to wiki: File:PBB Protein CLCN5 image.jpg {November 9, 2007 3:55:24 PM PST}
• CREATE: Found no pages, creating new page. {November 9, 2007 3:55:53 PM PST}
• CREATED: Created new protein page: CLCN5 {November 9, 2007 3:56:05 PM PST}

DYSF

• INFO: Beginning work on DYSF... {November 9, 2007 4:11:09 PM PST}
• AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 4:11:47 PM PST}

 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image =  
 | image_source =  
 | PDB = 
 | Name = Dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive)
 | HGNCid = 3097
 | Symbol = DYSF
 | AltSymbols =; FER1L1; FLJ00175; FLJ90168; LGMD2B
 | OMIM = 603009
 | ECnumber =  
 | Homologene = 20748
 | MGIid = 1349385
 | GeneAtlas_image1 = PBB_GE_DYSF_218660_at_tn.png
 | Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} 
 | Component = {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0042383 |text = sarcolemma}} 
 | Process = {{GNF_GO|id=GO:0001778 |text = plasma membrane repair}} {{GNF_GO|id=GO:0006936 |text = muscle contraction}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8291
    | Hs_Ensembl = ENSG00000135636
    | Hs_RefseqProtein = NP_003485
    | Hs_RefseqmRNA = NM_003494
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 2
    | Hs_GenLoc_start = 71534268
    | Hs_GenLoc_end = 71767398
    | Hs_Uniprot = O75923
    | Mm_EntrezGene = 26903
    | Mm_Ensembl = ENSMUSG00000033788
    | Mm_RefseqmRNA = NM_001077694
    | Mm_RefseqProtein = NP_001071162
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 6
    | Mm_GenLoc_start = 83985047
    | Mm_GenLoc_end = 84176717
    | Mm_Uniprot = Q7TQI2
  }}
}}
'''Dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive)''', also known as '''DYSF''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = The protein encoded by this gene belongs to the ferlin family and is a skeletal muscle protein found associated with the sarcolemma. It is involved in muscle contraction and contains C2 domains that play a role in calcium-mediated membrane fusion events, suggesting that it may be involved in membrane regeneration and repair. In addition, the protein encoded by this gene binds caveolin-3, a skeletal muscle membrane protein which is important in the formation of caveolae. Specific mutations in this gene have been shown to cause autosomal recessive limb girdle muscular dystrophy type 2B (LGMD2B) as well as Miyoshi myopathy.<ref>{{cite web | title = Entrez Gene: DYSF dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8291| accessdate = }}</ref>
}}

==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
}}
{{refend}}

{{protein-stub}}
 

HDAC6

• INFO: Beginning work on HDAC6... {November 9, 2007 4:18:27 PM PST}
• CREATE: Found no pages, creating new page. {November 9, 2007 4:19:47 PM PST}
• CREATED: Created new protein page: HDAC6 {November 9, 2007 4:19:56 PM PST}

MAD1L1

• INFO: Beginning work on MAD1L1... {November 9, 2007 4:11:47 PM PST}
• UPLOAD: Added new Image to wiki: File:PBB Protein MAD1L1 image.jpg {November 9, 2007 4:12:17 PM PST}
• AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 4:12:37 PM PST}

 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image = PBB_Protein_MAD1L1_image.jpg
 | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1go4.
 | PDB = {{PDB2|1go4}}
 | Name = MAD1 mitotic arrest deficient-like 1 (yeast)
 | HGNCid = 6762
 | Symbol = MAD1L1
 | AltSymbols =; MAD1; HsMAD1; PIG9; TP53I9; TXBP181
 | OMIM = 602686
 | ECnumber =  
 | Homologene = 74500
 | MGIid = 1341857
 | GeneAtlas_image1 = PBB_GE_MAD1L1_204857_at_tn.png
 | Function = {{GNF_GO|id=GO:0003674 |text = molecular_function}} 
 | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005813 |text = centrosome}} {{GNF_GO|id=GO:0005819 |text = spindle}} 
 | Process = {{GNF_GO|id=GO:0000089 |text = mitotic metaphase}} {{GNF_GO|id=GO:0000090 |text = mitotic anaphase}} {{GNF_GO|id=GO:0000093 |text = mitotic telophase}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007093 |text = mitotic cell cycle checkpoint}} {{GNF_GO|id=GO:0051301 |text = cell division}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8379
    | Hs_Ensembl = ENSG00000002822
    | Hs_RefseqProtein = NP_001013858
    | Hs_RefseqmRNA = NM_001013836
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 7
    | Hs_GenLoc_start = 1821956
    | Hs_GenLoc_end = 2236304
    | Hs_Uniprot = Q9Y6D9
    | Mm_EntrezGene = 17120
    | Mm_Ensembl = ENSMUSG00000029554
    | Mm_RefseqmRNA = NM_010752
    | Mm_RefseqProtein = NP_034882
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 5
    | Mm_GenLoc_start = 140261163
    | Mm_GenLoc_end = 140574024
    | Mm_Uniprot = Q9WTX8
  }}
}}
'''MAD1 mitotic arrest deficient-like 1 (yeast)''', also known as '''MAD1L1''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = MAD1L1 is a component of the mitotic spindle-assembly checkpoint that prevents the onset of anaphase until all chromosome are properly aligned at the metaphase plate. MAD1L1 functions as a homodimer and interacts with MAD2L1. MAD1L1 may play a role in cell cycle control and tumor suppression. Three transcript variants encoding the same protein have been found for this gene.<ref>{{cite web | title = Entrez Gene: MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8379| accessdate = }}</ref>
}}

==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
}}
{{refend}}

{{protein-stub}}
 

NR1H2

• INFO: Beginning work on NR1H2... {November 9, 2007 4:06:36 PM PST}
• UPLOAD: Added new Image to wiki: File:PBB Protein NR1H2 image.jpg {November 9, 2007 4:07:09 PM PST}
• AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 4:07:31 PM PST}

 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image = PBB_Protein_NR1H2_image.jpg
 | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1p8d.
 | PDB = {{PDB2|1p8d}}, {{PDB2|1pq6}}, {{PDB2|1pq9}}, {{PDB2|1pqc}}, {{PDB2|1upv}}, {{PDB2|1upw}}
 | Name = Nuclear receptor subfamily 1, group H, member 2
 | HGNCid = 7965
 | Symbol = NR1H2
 | AltSymbols =; UNR; LXR-b; LXRB; NER; NER-I; RIP15
 | OMIM = 600380
 | ECnumber =  
 | Homologene = 21397
 | MGIid = 1352463
 | GeneAtlas_image1 = PBB_GE_NR1H2_218215_s_at_tn.png
 | Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003707 |text = steroid hormone receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}} 
 | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} 
 | Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0016481 |text = negative regulation of transcription}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 7376
    | Hs_Ensembl = ENSG00000131408
    | Hs_RefseqProtein = NP_009052
    | Hs_RefseqmRNA = NM_007121
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 55571515
    | Hs_GenLoc_end = 55578030
    | Hs_Uniprot = P55055
    | Mm_EntrezGene = 22260
    | Mm_Ensembl = ENSMUSG00000060601
    | Mm_RefseqmRNA = XM_001002072
    | Mm_RefseqProtein = XP_001002072
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 44417659
    | Mm_GenLoc_end = 44421965
    | Mm_Uniprot = Q8BP65
  }}
}}
'''Nuclear receptor subfamily 1, group H, member 2''', also known as '''NR1H2''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = The LX receptors (LXRs) were originally identified as orphan members of the nuclear receptor superfamily because their ligands were unknown. Like other receptors in the family, LXRs heterodimerize with retinoid X receptor (see MIM 180245) and bind to specific response elements (LXREs) characterized by direct repeats separated by 4 nucleotides. Two genes, alpha (LXRA, MIM 602423) and beta, are known to encode LXR proteins (Song et al., 1995).[supplied by OMIM]<ref>{{cite web | title = Entrez Gene: NR1H2 nuclear receptor subfamily 1, group H, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7376| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Song C, Hiipakka RA, Kokontis JM, Liao S |title=Ubiquitous receptor: structures, immunocytochemical localization, and modulation of gene activation by receptors for retinoic acids and thyroid hormones. |journal=Ann. N. Y. Acad. Sci. |volume=761 |issue=  |pages= 38-49 |year= 1995 |pmid= 7625741 |doi=  }}
}}
{{refend}}

{{protein-stub}}
 

NRIP1

• INFO: Beginning work on NRIP1... {November 9, 2007 4:10:31 PM PST}
• CREATE: Found no pages, creating new page. {November 9, 2007 4:11:02 PM PST}
• CREATED: Created new protein page: NRIP1 {November 9, 2007 4:11:09 PM PST}

NUP214

• INFO: Beginning work on NUP214... {November 9, 2007 4:07:31 PM PST}
• UPLOAD: Added new Image to wiki: File:PBB Protein NUP214 image.jpg {November 9, 2007 4:08:31 PM PST}
• AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 4:08:51 PM PST}

 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image = PBB_Protein_NUP214_image.jpg
 | image_source = [[Protein_Data_Bank|PDB]] rendering based on 2oit.
 | PDB = {{PDB2|2oit}}
 | Name = Nucleoporin 214kDa
 | HGNCid = 8064
 | Symbol = NUP214
 | AltSymbols =; CAIN; CAN; D9S46E; MGC104525; N214
 | OMIM = 114350
 | ECnumber =  
 | Homologene = 38008
 | MGIid = 1095411
 | GeneAtlas_image1 = PBB_GE_NUP214_202155_s_at_tn.png
 | GeneAtlas_image2 = PBB_GE_NUP214_211261_at_tn.png
 | Function = {{GNF_GO|id=GO:0003674 |text = molecular_function}} {{GNF_GO|id=GO:0005215 |text = transporter activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0015288 |text = porin activity}} 
 | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005643 |text = nuclear pore}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0019867 |text = outer membrane}} 
 | Process = {{GNF_GO|id=GO:0006611 |text = protein export from nucleus}} {{GNF_GO|id=GO:0006810 |text = transport}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8021
    | Hs_Ensembl = ENSG00000126883
    | Hs_RefseqProtein = NP_005076
    | Hs_RefseqmRNA = NM_005085
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 9
    | Hs_GenLoc_start = 132990797
    | Hs_GenLoc_end = 133099878
    | Hs_Uniprot = P35658
    | Mm_EntrezGene = 227720
    | Mm_Ensembl = ENSMUSG00000001855
    | Mm_RefseqmRNA = XM_358340
    | Mm_RefseqProtein = XP_358340
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 31796490
    | Mm_GenLoc_end = 31874378
    | Mm_Uniprot =  
  }}
}}
'''Nucleoporin 214kDa''', also known as '''NUP214''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. This gene is a member of the FG-repeat-containing nucleoporins. The protein encoded by this gene is localized to the cytoplasmic face of the nuclear pore complex where it is required for proper cell cycle progression and nucleocytoplasmic transport. The 3' portion of this gene forms a fusion gene with the DEK gene on chromosome 6 in a t(6,9) translocation associated with acute myeloid leukemia and myelodysplastic syndrome.<ref>{{cite web | title = Entrez Gene: NUP214 nucleoporin 214kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8021| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Stoffler D, Fahrenkrog B, Aebi U |title=The nuclear pore complex: from molecular architecture to functional dynamics. |journal=Curr. Opin. Cell Biol. |volume=11 |issue= 3 |pages= 391-401 |year= 1999 |pmid= 10395558 |doi= 10.1016/S0955-0674(99)80055-6 }}
}}
{{refend}}

{{protein-stub}}
 

PDE5A

• INFO: Beginning work on PDE5A... {November 9, 2007 4:12:37 PM PST}
• UPLOAD: Added new Image to wiki: File:PBB Protein PDE5A image.jpg {November 9, 2007 4:13:27 PM PST}
• AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 4:13:46 PM PST}

 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image = PBB_Protein_PDE5A_image.jpg
 | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1rkp.
 | PDB = {{PDB2|1rkp}}, {{PDB2|1t9r}}, {{PDB2|1t9s}}, {{PDB2|1tbf}}, {{PDB2|1udt}}, {{PDB2|1udu}}, {{PDB2|1uho}}, {{PDB2|1xoz}}, {{PDB2|1xp0}}, {{PDB2|2chm}}, {{PDB2|2h40}}, {{PDB2|2h42}}, {{PDB2|2h44}}
 | Name = Phosphodiesterase 5A, cGMP-specific
 | HGNCid = 8784
 | Symbol = PDE5A
 | AltSymbols =; CGB-PDE; CN5A; PDE5; PDE5A1
 | OMIM = 603310
 | ECnumber =  
 | Homologene = 842
 | MGIid = 2651499
 | GeneAtlas_image1 = PBB_GE_PDE5A_206757_at_tn.png
 | Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0003824 |text = catalytic activity}} {{GNF_GO|id=GO:0004114 |text = 3',5'-cyclic-nucleotide phosphodiesterase activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}} {{GNF_GO|id=GO:0030553 |text = cGMP binding}} {{GNF_GO|id=GO:0047555 |text = 3',5'-cyclic-GMP phosphodiesterase activity}} 
 | Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}} 
 | Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0008150 |text = biological_process}} {{GNF_GO|id=GO:0009187 |text = cyclic nucleotide metabolic process}} {{GNF_GO|id=GO:0046069 |text = cGMP catabolic process}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8654
    | Hs_Ensembl = ENSG00000138735
    | Hs_RefseqProtein = NP_001074
    | Hs_RefseqmRNA = NM_001083
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 4
    | Hs_GenLoc_start = 120635000
    | Hs_GenLoc_end = 120769429
    | Hs_Uniprot = O76074
    | Mm_EntrezGene = 242202
    | Mm_Ensembl = ENSMUSG00000053965
    | Mm_RefseqmRNA = XM_001001000
    | Mm_RefseqProtein = XP_001001000
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 3
    | Mm_GenLoc_start = 122721180
    | Mm_GenLoc_end = 122848174
    | Mm_Uniprot = Q0VBW0
  }}
}}
'''Phosphodiesterase 5A, cGMP-specific''', also known as '''PDE5A''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = This gene encodes a cGMP-binding, cGMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family. This phosphodiesterase specifically hydrolyzes cGMP to 5'-GMP. It is involved in the regulation of intracellular concentrations of cyclic nucleotides and is important for smooth muscle relaxation in the cardiovascular system. Alternative splicing of this gene results in three transcript variants encoding distinct isoforms.<ref>{{cite web | title = Entrez Gene: PDE5A phosphodiesterase 5A, cGMP-specific| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8654| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Lin CS, Lin G, Xin ZC, Lue TF |title=Expression, distribution and regulation of phosphodiesterase 5. |journal=Curr. Pharm. Des. |volume=12 |issue= 27 |pages= 3439-57 |year= 2006 |pmid= 17017938 |doi=  }}
}}
{{refend}}

{{protein-stub}}
 

PICK1

• INFO: Beginning work on PICK1... {November 9, 2007 4:15:20 PM PST}
• UPLOAD: Added new Image to wiki: File:PBB Protein PICK1 image.jpg {November 9, 2007 4:15:58 PM PST}
• CREATE: Found no pages, creating new page. {November 9, 2007 4:16:11 PM PST}
• CREATED: Created new protein page: PICK1 {November 9, 2007 4:16:19 PM PST}

RAD23A

• INFO: Beginning work on RAD23A... {November 9, 2007 3:56:05 PM PST}
• UPLOAD: Added new Image to wiki: File:PBB Protein RAD23A image.jpg {November 9, 2007 3:57:25 PM PST}
• CREATE: Found no pages, creating new page. {November 9, 2007 3:57:37 PM PST}
• CREATED: Created new protein page: RAD23A {November 9, 2007 3:57:45 PM PST}

RBM8A

• INFO: Beginning work on RBM8A... {November 9, 2007 4:16:19 PM PST}
• UPLOAD: Added new Image to wiki: File:PBB Protein RBM8A image.jpg {November 9, 2007 4:17:54 PM PST}
• CREATE: Found no pages, creating new page. {November 9, 2007 4:18:20 PM PST}
• CREATED: Created new protein page: RBM8A {November 9, 2007 4:18:27 PM PST}

RHEB

• INFO: Beginning work on RHEB... {November 9, 2007 3:57:45 PM PST}
• UPLOAD: Added new Image to wiki: File:PBB Protein RHEB image.jpg {November 9, 2007 3:59:05 PM PST}
• CREATE: Found no pages, creating new page. {November 9, 2007 3:59:19 PM PST}
• CREATED: Created new protein page: RHEB {November 9, 2007 3:59:29 PM PST}

SAT1

• INFO: Beginning work on SAT1... {November 9, 2007 3:59:29 PM PST}
• UPLOAD: Added new Image to wiki: File:PBB Protein SAT1 image.jpg {November 9, 2007 4:00:41 PM PST}
• AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 4:01:01 PM PST}

 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image = PBB_Protein_SAT1_image.jpg
 | image_source = [[Protein_Data_Bank|PDB]] rendering based on 2b3u.
 | PDB = {{PDB2|2b3u}}, {{PDB2|2b3v}}, {{PDB2|2b4b}}, {{PDB2|2b4d}}, {{PDB2|2b58}}, {{PDB2|2b5g}}, {{PDB2|2f5i}}, {{PDB2|2fxf}}, {{PDB2|2g3t}}, {{PDB2|2jev}}
 | Name = Spermidine/spermine N1-acetyltransferase 1
 | HGNCid = 10540
 | Symbol = SAT1
 | AltSymbols =; DC21; KFSD; SAT; SSAT; SSAT-1
 | OMIM = 313020
 | ECnumber =  
 | Homologene = 37716
 | MGIid = 98233
 | GeneAtlas_image1 = PBB_GE_SAT1_203455_s_at_tn.png
 | GeneAtlas_image2 = PBB_GE_SAT1_210592_s_at_tn.png
 | GeneAtlas_image3 = PBB_GE_SAT1_213988_s_at_tn.png
 | Function = {{GNF_GO|id=GO:0004145 |text = diamine N-acetyltransferase activity}} {{GNF_GO|id=GO:0008080 |text = N-acetyltransferase activity}} {{GNF_GO|id=GO:0008415 |text = acyltransferase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} 
 | Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} 
 | Process = 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6303
    | Hs_Ensembl = ENSG00000130066
    | Hs_RefseqProtein = NP_002961
    | Hs_RefseqmRNA = NM_002970
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = X
    | Hs_GenLoc_start = 23711211
    | Hs_GenLoc_end = 23714264
    | Hs_Uniprot = P21673
    | Mm_EntrezGene = 20229
    | Mm_Ensembl =  
    | Mm_RefseqmRNA = NM_009121
    | Mm_RefseqProtein = NP_033147
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr =  
    | Mm_GenLoc_start =  
    | Mm_GenLoc_end =  
    | Mm_Uniprot =  
  }}
}}
'''Spermidine/spermine N1-acetyltransferase 1''', also known as '''SAT1''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = Spermidine/spermine N(1)-acetyltransferase (SPD/SPM acetyltransferase) is a rate-limiting enzyme in the catabolic pathway of polyamine metabolism. It catalyzes the N(1)-acetylation of spermidine and spermine and, by the successive activity of polyamine oxidase, spermine can be converted to spermidine and spermidine to putrescine.[supplied by OMIM]<ref>{{cite web | title = Entrez Gene: SAT1 spermidine/spermine N1-acetyltransferase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6303| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Lake JA, Carr J, Feng F, ''et al.'' |title=The role of Vif during HIV-1 infection: interaction with novel host cellular factors. |journal=J. Clin. Virol. |volume=26 |issue= 2 |pages= 143-52 |year= 2003 |pmid= 12600646 |doi=  }}
}}
{{refend}}

{{protein-stub}}
 

SLC5A1

• INFO: Beginning work on SLC5A1... {November 9, 2007 4:01:01 PM PST}
• AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 4:01:45 PM PST}

 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image =  
 | image_source =  
 | PDB = 
 | Name = Solute carrier family 5 (sodium/glucose cotransporter), member 1
 | HGNCid = 11036
 | Symbol = SLC5A1
 | AltSymbols =; D22S675; NAGT; SGLT1
 | OMIM = 182380
 | ECnumber =  
 | Homologene = 55456
 | MGIid = 107678
 | GeneAtlas_image1 = PBB_GE_SLC5A1_206628_at_tn.png
 | Function = {{GNF_GO|id=GO:0005215 |text = transporter activity}} {{GNF_GO|id=GO:0005351 |text = sugar:hydrogen ion symporter activity}} {{GNF_GO|id=GO:0005412 |text = glucose:sodium symporter activity}} {{GNF_GO|id=GO:0015293 |text = symporter activity}} {{GNF_GO|id=GO:0031402 |text = sodium ion binding}} 
 | Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0005903 |text = brush border}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016324 |text = apical plasma membrane}} 
 | Process = {{GNF_GO|id=GO:0001656 |text = metanephros development}} {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0006814 |text = sodium ion transport}} {{GNF_GO|id=GO:0015758 |text = glucose transport}} {{GNF_GO|id=GO:0050892 |text = intestinal absorption}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6523
    | Hs_Ensembl = ENSG00000100170
    | Hs_RefseqProtein = NP_000334
    | Hs_RefseqmRNA = NM_000343
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 22
    | Hs_GenLoc_start = 30769259
    | Hs_GenLoc_end = 30836645
    | Hs_Uniprot = P13866
    | Mm_EntrezGene = 20537
    | Mm_Ensembl = ENSMUSG00000011034
    | Mm_RefseqmRNA = NM_019810
    | Mm_RefseqProtein = NP_062784
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 5
    | Mm_GenLoc_start = 33421091
    | Mm_GenLoc_end = 33479554
    | Mm_Uniprot = O70122
  }}
}}
'''Solute carrier family 5 (sodium/glucose cotransporter), member 1''', also known as '''SLC5A1''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = Glucose transporters are integral membrane proteins that mediate the transport of glucose and structurally-related substances across cellular membranes. Two families of glucose transporter have been identified: the facilitated-diffusion glucose transporter family (GLUT family), also known as 'uniporters,' and the sodium-dependent glucose transporter family (SGLT family), also known as 'cotransporters' or 'symporters' (Wright et al., 1994). The SLC5A1 gene encodes a protein that is involved in the active transport of glucose and galactose into eukaryotic and some prokaryotic cells.[supplied by OMIM]<ref>{{cite web | title = Entrez Gene: SLC5A1 solute carrier family 5 (sodium/glucose cotransporter), member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6523| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Wright EM, Loo DD, Panayotova-Heiermann M, ''et al.'' |title='Active' sugar transport in eukaryotes. |journal=J. Exp. Biol. |volume=196 |issue=  |pages= 197-212 |year= 1995 |pmid= 7823022 |doi=  }}
*{{cite journal  | author=Wright EM, Turk E, Martin MG |title=Molecular basis for glucose-galactose malabsorption. |journal=Cell Biochem. Biophys. |volume=36 |issue= 2-3 |pages= 115-21 |year= 2003 |pmid= 12139397 |doi=  }}
*{{cite journal  | author=Anderson NL, Anderson NG |title=The human plasma proteome: history, character, and diagnostic prospects. |journal=Mol. Cell Proteomics |volume=1 |issue= 11 |pages= 845-67 |year= 2003 |pmid= 12488461 |doi=  }}
}}
{{refend}}

{{protein-stub}}
 

SNRPN

• INFO: Beginning work on SNRPN... {November 9, 2007 4:01:45 PM PST}
• UPLOAD: Added new Image to wiki: File:PBB Protein SNRPN image.jpg {November 9, 2007 4:01:58 PM PST}
• AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 4:02:19 PM PST}

 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image = PBB_Protein_SNRPN_image.jpg
 | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1d3b.
 | PDB = {{PDB2|1d3b}}
 | Name = Small nuclear ribonucleoprotein polypeptide N
 | HGNCid = 11164
 | Symbol = SNRPN
 | AltSymbols =; SMN; HCERN3; RT-LI; SM-D; SNRNP-N; SNURF-SNRPN
 | OMIM = 182279
 | ECnumber =  
 | Homologene = 68297
 | MGIid = 98347
 | Function = {{GNF_GO|id=GO:0003674 |text = molecular_function}} {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0042802 |text = identical protein binding}} 
 | Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005681 |text = spliceosome}} {{GNF_GO|id=GO:0030529 |text = ribonucleoprotein complex}} {{GNF_GO|id=GO:0030532 |text = small nuclear ribonucleoprotein complex}} 
 | Process = {{GNF_GO|id=GO:0008150 |text = biological_process}} {{GNF_GO|id=GO:0008380 |text = RNA splicing}} {{GNF_GO|id=GO:0016071 |text = mRNA metabolic process}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6638
    | Hs_Ensembl =  
    | Hs_RefseqProtein = NP_003088
    | Hs_RefseqmRNA = NM_003097
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr =  
    | Hs_GenLoc_start =  
    | Hs_GenLoc_end =  
    | Hs_Uniprot =  
    | Mm_EntrezGene = 20646
    | Mm_Ensembl = ENSMUSG00000000948
    | Mm_RefseqmRNA = NM_013670
    | Mm_RefseqProtein = NP_038698
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 59862190
    | Mm_GenLoc_end = 59866513
    | Mm_Uniprot = O70499
  }}
}}
'''Small nuclear ribonucleoprotein polypeptide N''', also known as '''SNRPN''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = The protein encoded by this gene is one polypeptide of a small nuclear ribonucleoprotein complex and belongs to the snRNP SMB/SMN family. The protein plays a role in pre-mRNA processing, possibly tissue-specific alternative splicing events. Although individual snRNPs are believed to recognize specific nucleic acid sequences through RNA-RNA base pairing, the specific role of this family member is unknown. The protein arises from a bicistronic transcript that also encodes a protein identified as the SNRPN upstream reading frame (SNURF). Multiple transcription initiation sites have been identified and extensive alternative splicing occurs in the 5' untranslated region. Additional splice variants have been described but sequences for the complete transcripts have not been determined. The 5' UTR of this gene has been identified as an imprinting center. Alternative splicing or deletion caused by a translocation event in this paternally-expressed region is responsible for Angelman syndrome or Prader-Willi syndrome due to parental imprint switch failure.<ref>{{cite web | title = Entrez Gene: SNRPN small nuclear ribonucleoprotein polypeptide N| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6638| accessdate = }}</ref>
}}

==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
}}
{{refend}}

{{protein-stub}}
 

SPN

• INFO: Beginning work on SPN... {November 9, 2007 4:02:19 PM PST}
• AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 4:02:37 PM PST}

 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image =  
 | image_source =  
 | PDB = 
 | Name = Sialophorin (leukosialin, CD43)
 | HGNCid = 11249
 | Symbol = SPN
 | AltSymbols =; CD43; GPL115; LSN
 | OMIM = 182160
 | ECnumber =  
 | Homologene = 36108
 | MGIid = 98384
 | Function = {{GNF_GO|id=GO:0004888 |text = transmembrane receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008367 |text = bacterial binding}} 
 | Component = {{GNF_GO|id=GO:0001931 |text = uropod}} {{GNF_GO|id=GO:0005604 |text = basement membrane}} {{GNF_GO|id=GO:0005615 |text = extracellular space}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0009897 |text = external side of plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} 
 | Process = {{GNF_GO|id=GO:0001562 |text = response to protozoan}} {{GNF_GO|id=GO:0001808 |text = negative regulation of type IV hypersensitivity}} {{GNF_GO|id=GO:0006935 |text = chemotaxis}} {{GNF_GO|id=GO:0006968 |text = cellular defense response}} {{GNF_GO|id=GO:0007162 |text = negative regulation of cell adhesion}} {{GNF_GO|id=GO:0007163 |text = establishment and/or maintenance of cell polarity}} {{GNF_GO|id=GO:0007166 |text = cell surface receptor linked signal transduction}} {{GNF_GO|id=GO:0008624 |text = induction of apoptosis by extracellular signals}} {{GNF_GO|id=GO:0031295 |text = T cell costimulation}} {{GNF_GO|id=GO:0042102 |text = positive regulation of T cell proliferation}} {{GNF_GO|id=GO:0042130 |text = negative regulation of T cell proliferation}} {{GNF_GO|id=GO:0042535 |text = positive regulation of tumor necrosis factor biosynthetic process}} {{GNF_GO|id=GO:0042742 |text = defense response to bacterium}} {{GNF_GO|id=GO:0045060 |text = negative thymic T cell selection}} {{GNF_GO|id=GO:0050688 |text = regulation of antiviral response}} {{GNF_GO|id=GO:0050776 |text = regulation of immune response}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6693
    | Hs_Ensembl = ENSG00000197471
    | Hs_RefseqProtein = NP_001025459
    | Hs_RefseqmRNA = NM_001030288
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 16
    | Hs_GenLoc_start = 29582077
    | Hs_GenLoc_end = 29589688
    | Hs_Uniprot = P16150
    | Mm_EntrezGene = 20737
    | Mm_Ensembl = ENSMUSG00000051457
    | Mm_RefseqmRNA = NM_001037810
    | Mm_RefseqProtein = NP_001032899
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 126924612
    | Mm_GenLoc_end = 126928965
    | Mm_Uniprot = Q544C5
  }}
}}
'''Sialophorin (leukosialin, CD43)''', also known as '''SPN''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = Sialophorin (leukosialin) is a major sialoglycoprotein on the surface of human T lymphocytes, monocytes, granulocytes, and some B lymphocytes, which appears to be important for immune function and may be part of a physiologic ligand-receptor complex involved in T-cell activation.[supplied by OMIM]<ref>{{cite web | title = Entrez Gene: SPN sialophorin (leukosialin, CD43)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6693| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Fukuda M, Carlsson SR |title=Leukosialin, a major sialoglycoprotein on human leukocytes as differentiation antigens. |journal=Med. Biol. |volume=64 |issue= 6 |pages= 335-43 |year= 1987 |pmid= 2950285 |doi=  }}
}}
{{refend}}

{{protein-stub}}
 

ST14

• INFO: Beginning work on ST14... {November 9, 2007 4:02:37 PM PST}
• UPLOAD: Added new Image to wiki: File:PBB Protein ST14 image.jpg {November 9, 2007 4:03:30 PM PST}
• AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 4:03:53 PM PST}

 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image = PBB_Protein_ST14_image.jpg
 | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1eaw.
 | PDB = {{PDB2|1eaw}}, {{PDB2|1eax}}, {{PDB2|2gv6}}, {{PDB2|2gv7}}
 | Name = Suppression of tumorigenicity 14 (colon carcinoma)
 | HGNCid = 11344
 | Symbol = ST14
 | AltSymbols =; HAI; MT-SP1; MTSP-1; MTSP1; PRSS14; SNC19; TADG-15
 | OMIM = 606797
 | ECnumber =  
 | Homologene = 7906
 | MGIid = 1338881
 | GeneAtlas_image1 = PBB_GE_ST14_202005_at_tn.png
 | GeneAtlas_image2 = PBB_GE_ST14_216905_s_at_tn.png
 | Function = {{GNF_GO|id=GO:0004252 |text = serine-type endopeptidase activity}} 
 | Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0019897 |text = extrinsic to plasma membrane}} 
 | Process = {{GNF_GO|id=GO:0006508 |text = proteolysis}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6768
    | Hs_Ensembl = ENSG00000149418
    | Hs_RefseqProtein = NP_068813
    | Hs_RefseqmRNA = NM_021978
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 129534892
    | Hs_GenLoc_end = 129585466
    | Hs_Uniprot = Q9Y5Y6
    | Mm_EntrezGene = 19143
    | Mm_Ensembl = ENSMUSG00000031995
    | Mm_RefseqmRNA = NM_011176
    | Mm_RefseqProtein = NP_035306
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 9
    | Mm_GenLoc_start = 30838155
    | Mm_GenLoc_end = 30881364
    | Mm_Uniprot = Q543E3
  }}
}}
'''Suppression of tumorigenicity 14 (colon carcinoma)''', also known as '''ST14''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = The protein encoded by this gene is an epithelial-derived, integral membrane serine protease. This protease forms a complex with the Kunitz-type serine protease inhibitor, HAI-1, and is found to be activated by sphingosine 1-phosphate. This protease has been shown to cleave and activate hepatocyte growth factor/scattering factor, and urokinase plasminogen activator, which suggest the function of this protease as an epithelial membrane activator for other proteases and latent growth factors. The expression of this protease has been associated with breast, colon, prostate, and ovarian tumors, which implicates its role in cancer invasion, and metastasis.<ref>{{cite web | title = Entrez Gene: ST14 suppression of tumorigenicity 14 (colon carcinoma)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6768| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Uhland K |title=Matriptase and its putative role in cancer. |journal=Cell. Mol. Life Sci. |volume=63 |issue= 24 |pages= 2968-78 |year= 2007 |pmid= 17131055 |doi= 10.1007/s00018-006-6298-x }}
}}
{{refend}}

{{protein-stub}}
 

THY1

• INFO: Beginning work on THY1... {November 9, 2007 4:03:53 PM PST}
• AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 4:05:10 PM PST}

 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image =  
 | image_source =  
 | PDB = 
 | Name = Thy-1 cell surface antigen
 | HGNCid = 11801
 | Symbol = THY1
 | AltSymbols =; CD90; FLJ33325
 | OMIM = 188230
 | ECnumber =  
 | Homologene = 4580
 | MGIid = 98747
 | GeneAtlas_image1 = PBB_GE_THY1_208850_s_at_tn.png
 | GeneAtlas_image2 = PBB_GE_THY1_208851_s_at_tn.png
 | GeneAtlas_image3 = PBB_GE_THY1_213869_x_at_tn.png
 | Function = {{GNF_GO|id=GO:0003674 |text = molecular_function}} {{GNF_GO|id=GO:0005100 |text = Rho GTPase activator activity}} {{GNF_GO|id=GO:0005178 |text = integrin binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0048503 |text = GPI anchor binding}} 
 | Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}} {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0005829 |text = cytosol}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0009897 |text = external side of plasma membrane}} {{GNF_GO|id=GO:0030426 |text = growth cone}} {{GNF_GO|id=GO:0045121 |text = lipid raft}} 
 | Process = {{GNF_GO|id=GO:0001525 |text = angiogenesis}} {{GNF_GO|id=GO:0006469 |text = negative regulation of protein kinase activity}} {{GNF_GO|id=GO:0007010 |text = cytoskeleton organization and biogenesis}} {{GNF_GO|id=GO:0008150 |text = biological_process}} {{GNF_GO|id=GO:0016337 |text = cell-cell adhesion}} {{GNF_GO|id=GO:0030336 |text = negative regulation of cell migration}} {{GNF_GO|id=GO:0043066 |text = negative regulation of apoptosis}} {{GNF_GO|id=GO:0043547 |text = positive regulation of GTPase activity}} {{GNF_GO|id=GO:0045576 |text = mast cell activation}} {{GNF_GO|id=GO:0046549 |text = retinal cone cell development}} {{GNF_GO|id=GO:0048041 |text = focal adhesion formation}} {{GNF_GO|id=GO:0048147 |text = negative regulation of fibroblast proliferation}} {{GNF_GO|id=GO:0050731 |text = positive regulation of peptidyl-tyrosine phosphorylation}} {{GNF_GO|id=GO:0050771 |text = negative regulation of axonogenesis}} {{GNF_GO|id=GO:0050852 |text = T cell receptor signaling pathway}} {{GNF_GO|id=GO:0050860 |text = negative regulation of T cell receptor signaling pathway}} {{GNF_GO|id=GO:0050870 |text = positive regulation of T cell activation}} {{GNF_GO|id=GO:0051281 |text = positive regulation of release of sequestered calcium ion into cytosol}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 7070
    | Hs_Ensembl = ENSG00000154096
    | Hs_RefseqProtein = NP_006279
    | Hs_RefseqmRNA = NM_006288
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 118794096
    | Hs_GenLoc_end = 118800048
    | Hs_Uniprot = P04216
    | Mm_EntrezGene = 21838
    | Mm_Ensembl = ENSMUSG00000032011
    | Mm_RefseqmRNA = NM_009382
    | Mm_RefseqProtein = NP_033408
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 9
    | Mm_GenLoc_start = 43796949
    | Mm_GenLoc_end = 43799574
    | Mm_Uniprot = Q53YX2
  }}
}}
'''Thy-1 cell surface antigen''', also known as '''THY1''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = 
}}

==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Henniker AJ |title=CD90. |journal=J. Biol. Regul. Homeost. Agents |volume=15 |issue= 4 |pages= 392-3 |year= 2002 |pmid= 11860231 |doi=  }}
}}
{{refend}}

{{protein-stub}}
 

TP53BP2

• INFO: Beginning work on TP53BP2... {November 9, 2007 4:05:10 PM PST}
• UPLOAD: Added new Image to wiki: File:PBB Protein TP53BP2 image.jpg {November 9, 2007 4:05:43 PM PST}
• AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 4:06:01 PM PST}

 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image = PBB_Protein_TP53BP2_image.jpg
 | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1ycs.
 | PDB = {{PDB2|1ycs}}
 | Name = Tumor protein p53 binding protein, 2
 | HGNCid = 12000
 | Symbol = TP53BP2
 | AltSymbols =; 53BP2; ASPP2; BBP; PPP1R13A; p53BP2
 | OMIM = 602143
 | ECnumber =  
 | Homologene = 3959
 | MGIid = 2138319
 | GeneAtlas_image1 = PBB_GE_TP53BP2_203120_at_tn.png
 | Function = {{GNF_GO|id=GO:0005070 |text = SH3/SH2 adaptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0051059 |text = NF-kappaB binding}} 
 | Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} 
 | Process = {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0006917 |text = induction of apoptosis}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007417 |text = central nervous system development}} {{GNF_GO|id=GO:0007507 |text = heart development}} {{GNF_GO|id=GO:0009792 |text = embryonic development ending in birth or egg hatching}} {{GNF_GO|id=GO:0010212 |text = response to ionizing radiation}} {{GNF_GO|id=GO:0045786 |text = negative regulation of progression through cell cycle}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 7159
    | Hs_Ensembl = ENSG00000143514
    | Hs_RefseqProtein = NP_001026855
    | Hs_RefseqmRNA = NM_001031685
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 222034224
    | Hs_GenLoc_end = 222100297
    | Hs_Uniprot = Q13625
    | Mm_EntrezGene = 209456
    | Mm_Ensembl = ENSMUSG00000026510
    | Mm_RefseqmRNA = NM_173378
    | Mm_RefseqProtein = NP_775554
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 1
    | Mm_GenLoc_start = 184265679
    | Mm_GenLoc_end = 184299107
    | Mm_Uniprot = Q3UZC5
  }}
}}
'''Tumor protein p53 binding protein, 2''', also known as '''TP53BP2''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. It is localized to the perinuclear region of the cytoplasm, and regulates apoptosis and cell growth through interactions with other regulatory molecules including members of the p53 family. Multiple transcript variants encoding different isoforms have been found for this gene.<ref>{{cite web | title = Entrez Gene: TP53BP2 tumor protein p53 binding protein, 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7159| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Liu ZJ, Lu X, Zhong S |title=ASPP--Apoptotic specific regulator of p53. |journal=Biochim. Biophys. Acta |volume=1756 |issue= 1 |pages= 77-80 |year= 2005 |pmid= 16139958 |doi= 10.1016/j.bbcan.2005.08.002 }}
}}
{{refend}}

{{protein-stub}}
 

UCP1

• INFO: Beginning work on UCP1... {November 9, 2007 4:06:01 PM PST}
• AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 4:06:36 PM PST}

 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image =  
 | image_source =  
 | PDB = 
 | Name = Uncoupling protein 1 (mitochondrial, proton carrier)
 | HGNCid = 12517
 | Symbol = UCP1
 | AltSymbols =; SLC25A7; UCP
 | OMIM = 113730
 | ECnumber =  
 | Homologene = 22524
 | MGIid = 98894
 | GeneAtlas_image1 = PBB_GE_UCP1_221384_at_tn.png
 | Function = {{GNF_GO|id=GO:0005215 |text = transporter activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0017077 |text = oxidative phosphorylation uncoupler activity}} 
 | Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005739 |text = mitochondrion}} {{GNF_GO|id=GO:0005740 |text = mitochondrial envelope}} {{GNF_GO|id=GO:0005743 |text = mitochondrial inner membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} 
 | Process = {{GNF_GO|id=GO:0006091 |text = generation of precursor metabolites and energy}} {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0006839 |text = mitochondrial transport}} {{GNF_GO|id=GO:0015992 |text = proton transport}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 7350
    | Hs_Ensembl = ENSG00000109424
    | Hs_RefseqProtein = NP_068605
    | Hs_RefseqmRNA = NM_021833
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 4
    | Hs_GenLoc_start = 141700500
    | Hs_GenLoc_end = 141709457
    | Hs_Uniprot = P25874
    | Mm_EntrezGene = 22227
    | Mm_Ensembl = ENSMUSG00000031710
    | Mm_RefseqmRNA = NM_009463
    | Mm_RefseqProtein = NP_033489
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 8
    | Mm_GenLoc_start = 86180457
    | Mm_GenLoc_end = 86188557
    | Mm_Uniprot = P12242
  }}
}}
'''Uncoupling protein 1 (mitochondrial, proton carrier)''', also known as '''UCP1''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = Mitochondrial uncoupling proteins (UCP) are members of the family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed only in brown adipose tissue, a specialized tissue which functions to produce heat.<ref>{{cite web | title = Entrez Gene: UCP1 uncoupling protein 1 (mitochondrial, proton carrier)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7350| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Ricquier D, Bouillaud F |title=The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP. |journal=Biochem. J. |volume=345 Pt 2 |issue=  |pages= 161-79 |year= 2000 |pmid= 10620491 |doi=  }}
*{{cite journal  | author=Muzzin P |title=The uncoupling proteins. |journal=Ann. Endocrinol. (Paris) |volume=63 |issue= 2 Pt 1 |pages= 106-10 |year= 2002 |pmid= 11994670 |doi=  }}
*{{cite journal  | author=Del Mar Gonzalez-Barroso M, Ricquier D, Cassard-Doulcier AM |title=The human uncoupling protein-1 gene (UCP1): present status and perspectives in obesity research. |journal=Obesity reviews : an official journal of the International Association for the Study of Obesity |volume=1 |issue= 2 |pages= 61-72 |year= 2002 |pmid= 12119988 |doi=  }}
}}
{{refend}}

{{protein-stub}}
 

end log.