VAP protein family
| VAMP-associated membrane protein | |
|---|---|
| Identifiers | |
| Symbol | VAP |
| InterPro | IPR016763 |
| Membranome | 202 |
VAP proteins are conserved
Humans have two VAPs that consist of the essential Major Sperm Protein domain and linker plus transmembrane helix) to attach to the ER: VAPA and VAPB.[3] A third VAP-like protein is Motile sperm domain containing 2 (MOSPD2), which has all the elements of VAP, and like them binds FFAT motifs, but has at its N-terminus a CRAL-TRIO domain that can bind and transfer lipids.[4]
VAP includes the whole family of
protein homologues in all species. For example, baker's yeast expresses two VAPs: Scs2 and Scs22.[5][6]