Virginia Zakian
Virginia Zakian | |
---|---|
Alma mater | Fred Hutchinson Cancer Research Center |
Doctoral students | Wai-Hong Tham |
Virginia Zakian is the Harry C. Wiess Professor in the Life Sciences in the Department of Molecular Biology at
Education and career
Zakian completed her
In 1978, Zakian joined the
In 1995, Zakian was appointed as a professor in the Department of Molecular Biology at Princeton University.[2] Zakian was awarded the Harry C. Wiess Professor in the Life Sciences in the Department of Molecular Biology in the year 2000, a position that she holds to this day.[6] Zakian served as the chair of "Princeton's Task force on the Status of Women Faculty in the Natural Sciences and Engineering at Princeton." from 2001-2003, in 2003 Zakian became Princeton University's representative to Nine Universities, Gender Equity Analysis[2][3]
Research Area
Zakian has published 150 papers in peer-reviewed journals throughout her career.
Zakian, along with GM Dani, "were the first to construct and characterize a linear artificial chromosome." in 1983.[1] This work, along with another related study[8] helped to introduce the "use ciliate telomeres to generate linear yeast episomes, a strategy that began the molecular era of yeast telomere biology"[1] Zakian, working with a team of other researchers in the paper "Position effect at S. cerevisiae telomeres: reversible repression of Pol II transcription" (Gottschling et al. 1990 Cell)[9] "discovered telomere position effect, TPE, the transcriptional repression of genes near telomeres in budding yeast."[1] In 1994, Zakian, along with Schulz, "identified the Pif1p DNA helicase as an inhibitor of telomere lengthening and especially of telomere formation."[7] In "Pif1p helicase, a catalytic inhibitor of telomerase in yeast."[10] a team of researchers, including Zakian, found that "Pif1p-like helicases are found in diverse organisms, including humans" and that "Pif1p is the prototype member of a helicase subfamily"[1] The team proposed that "Pif1p-mediated inhibition of telomerase promotes genetic stability by suppressing telomerase-mediated healing of double-strand breaks."[10] Ivessa, Zhou and Zakian later discovered another, "highly connected," member of Pif1p's "helicase subfamily" called Rrm3p.[7] In their paper they found that both Pif1p and Rrm3p both "affected rDNA replication but had opposing effects on fork progression." On the one hand, "Pif1p helped maintain the replication fork progression" while "Rrm3p appears to be the replicative helicase for rDNA as it acted catalytically to promote fork progression throughout the rDNA."[11]
Selected publications
- Zakian, Virginia (8 December 1995). "Telomeres: Beginning to Understand the End". Science. 270 (5242): 1601–1607. S2CID 26674893.
- Zakian, Virginia; Dani GM (June 1983). "Mitotic and meiotic stability of linear plasmids in yeast". PNAS. 80 (11): 3406–10. PMID 6344082.
- Zakian, Virginia; Gottschling DE (24 October 1986). "Telomere proteins: specific recognition and protection of the natural termini of Oxytricha macronuclear DNA". Cell. 47 (2): 195–205. S2CID 9999407.
- Zakian, Virginia; Daniel E. Gottschling; Oscar M. Aparicio; Barbara L. Billington (16 November 1990). "Position effect at S. cerevisiae telomeres: Reversible repression of Pol II transcription". Cell. 63 (4): 751–762. S2CID 21940834.
- Zakian, Virginia; Boulé, JB; Vega, LR (3 November 2005). "The yeast Pif1p helicase removes telomerase from telomeric DNA". Nature. 438 (7064): 57–61. S2CID 4411655.
References
- ^ a b c d e "Zakian Summary of Research Accomplishments". Zakian Lab. Archived from the original on 2010-06-19.
- ^ a b c d e f g h i j k "Virginia A. Zakian Biographical Information". Zakian Lab. Archived from the original on 2006-09-01.
- ^ a b c "Virginia Zakian". Princeton University. Archived from the original on 2007-11-22.
- ^ "Virginia A. Zakian". American Academy of Arts & Sciences. Retrieved 2021-02-11.
- ^ a b "Zakian Publications". Zakian Lab. Archived from the original on 2006-09-03.
- ^ "Endowed Professors and other chairs". Princeton University. Archived from the original on 2008-05-14.
- ^ a b c d "Virginia A. Zakian". Princeton. Retrieved 2013-10-14.
- PMID 6324194.
- S2CID 21940834. Retrieved 2013-10-14.
- ^ PMID 10926538.
- PMID 10693764.