Zellweger spectrum disorders

Source: Wikipedia, the free encyclopedia.

Zellweger spectrum disorders are a group of

kidneys, eyes, and hearing.[3] It is named after Hans Zellweger
.

Signs and symptoms

The symptoms of the disorders can vary from every patient. Most symptoms are noticeable at birth. There is often lack in growth and muscle tone as the child develops. Also the disorders involve neurological problems. This would include frequent

reflexes.[citation needed
]

Facial abnormalities are also often common with patients. Including a small chin, upturned nostrils, and a mouth with a highly arched roof. There are also a variety of eye abnormalities that could happen. The eye abnormalities including clouding of the

cataracts and retinopathy, which can lead to vision loss. Children with Zellweger Spectrum disorder can have hearing loss with onset during the first months following birth.[4]

Infants with the disorder can also have abnormalities including their organs. They might have a large spleen or liver, as well as heart defects. Including holes in the heart, and high blood pressure. Due to the lack of muscle tone, infants can face respiratory problems as the disease progresses.[citation needed]

Causes

Zellweger spectrum disorders are a group of autosomal recessive

organelles in the body that are meant to breakdown items like acids and toxic compounds. Both parents will have to have the recessive gene for the child to show symptoms. If one parent has the gene and the other one does not, the child will be a carrier and will not show symptoms. Any mutation involving the genes that create or work the peroxisomes can lead to the development of any of the Zellweger Spectrum Disorders. Both genders have an equal chance to end up with these disorders.[citation needed
]

Diagnosis

Definite diagnosis requires evaluation of peroxisomal functions.[5] Mutation analysis is done from fibroblast cell lines.[6]

Treatment

Treatment may involve a team of specialists. This would include

pediatricians.[citation needed
]

Early intervention is important when treating someone with these disorders. Special education, physical therapy, and other medical services to aid the child through treatment. There are medical trials taking place to learn more about these disorders. Most infants that are diagnosed do not live past 6 months. It can be diagnosed by a blood test looking for PEX genes in the body.[clarification needed][7]

Epidemiology

It occurs in 1 in 50,000 individuals.[8]

References

  1. ^ "zellweger". Zellweger UK. Retrieved 20 February 2018.
  2. ^ "Zellweger Spectrum Disorders". University of Michigan. Retrieved 20 February 2018.
  3. ^ "Zellweger Spectrum Disorder". National Organization of Rare Diseases. Retrieved 20 February 2018.
  4. ^ "Zellweger Syndrome". Hereditary Ocular Diseases. Retrieved 20 February 2018.
  5. ^
    PMID 26287655
    .
  6. S2CID 24977902
    .
  7. ^ "Zellweger Spectrum Disorder". Johns Hopkins Medicine. Retrieved 20 February 2018.
  8. ^ "Zellweger Spectrum Disorders". U.S National Library of Medicine. Retrieved 20 February 2018.
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