16α-LE2

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16α-LE2
Identifiers
  • 3,17β-Dihydroxy-16α,21-epoxy-19-nor-17α-pregna-1,3,5(10)-trien-21-one
JSmol)
  • O=C1O[C@@]2([H])[C@]([C@@]3(C)CC[C@]4([H])C5=CC=C(C=C5CC[C@@]4([H])[C@]3([H])C2)O)(C1)O
  • InChI=InChI=1S/C20H24O4/c1-19-7-6-14-13-5-3-12(21)8-11(13)2-4-15(14)16(19)9-17-20(19,23)10-18(22)24-17/h3,5,8,14-17,21,23H,2,4,6-7,9-10H2,1H3/t14-,15-,16+,17-,19+,20+/m1/s1
  • Key:NLUGVTJBNRSIKH-UQZPWQSVSA-N

16α-LE2, or 16α-lactone-estradiol, also known as 3,17β-dihydroxy-19-nor-17α-pregna-1,3,5-(10)-triene-21,16α-lactone, is a

binding affinity for the ERα over the ERβ.[2]

In rodents, 16α-LE2 has no effect on

bone mineral density are mediated via the ERα, whereas the ERβ does not appear to be involved.[4]

See also

References

  1. ISBN 978-1-84569-574-3
    .
  2. ^
    PMID 15037755
    .
  3. ISBN 978-0-12-397769-4
    .
  4. S2CID 1774519
    .
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