4-DAMP

4-DAMP

Names
Preferred IUPAC name 4-[(Diphenylacetyl)oxy]-1,1-dimethylpiperidin-1-ium iodide
Other names 4-(2,2-Diphenylacetoxy)-1,1-dimethylpiperidin-1-ium iodide
Identifiers
CAS Number	1952-15-4 Y
3D model ( JSmol )	Interactive image
ChemSpider	2282596
PubChem CID	3014059
UNII	CP6GVV66RG Y
CompTox Dashboard (EPA)	DTXSID40941281
InChI InChI=1S/C21H26NO2.HI/c1-22(2)15-13-19(14-16-22)24-21(23)20(17-9-5-3-6-10-17)18-11-7-4-8-12-18;/h3-12,19-20H,13-16H2,1-2H3;1H/q+1;/p-1 Key: WWJHRSCUAQPFQO-UHFFFAOYSA-M
SMILES [I-].C[N+]1(C)CCC(CC1)OC(=O)C(C1=CC=CC=C1)C1=CC=CC=C1
Properties
Chemical formula	C21H26INO2
Molar mass	451.348 g·mol−1
Appearance	White to beige powder[1]
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

4-DAMP (1,1-dimethyl-4-diphenylacetoxypiperidinium iodide) is a selective muscarinic acetylcholine receptor (mAChR) M₃ antagonist.^[2] It is also able to antagonize M₁ receptors but "prefers" M₃.^[3][4] It competitively binds to the acetylcholine binding site on mAChRs, causing right-ward shift in the dose response curves for mAChR agonists.

References