5-Carboxamidotryptamine

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5-Carboxamidotryptamine
Clinical data
Other names5-CT; 5-(Aminocarbonyl)tryptamine
Identifiers
  • 3-(2-Aminoethyl)-1H-indole-5-carboxamide
JSmol)
SMILES
  • C1=CC2=C(C=C1C(=O)N)C(=CN2)CCN
  • InChI=1S/C11H13N3O/c12-4-3-8-6-14-10-2-1-7(11(13)15)5-9(8)10/h1-2,5-6,14H,3-4,12H2,(H2,13,15) checkY
  • Key:WKZLNEWVIAGNAW-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

5-Carboxamidotryptamine (5-CT), also known as 5-(aminocarbonyl)tryptamine, is a

derivative closely related to the neurotransmitter serotonin.[1]

5-CT acts as a

5-HT1F receptors.[6][1] 5-CT binds most strongly to the 5-HT1A receptor and it was once thought to be selective for this site.[7][8][1]

In 2018, a close derivative of 5-CT,

5-HT1A.[9] Structural study indicated residue Ser5x43 might play critical roles in the selectivity of 5-CT across the serotonin receptor family.[10]

See also

References

  1. ^
    PMID 3543362
    . Table II. Affinities of Selected Phenalkylamines for 5-HT1 and 5-HT2 Binding Sites
  2. PMID 9831297
    .
  3. PMID 2470992
    .
  4. ^ Glennon RA, Dukat M, Westkaemper RB (2000-01-01). "Serotonin Receptor Subtypes and Ligands". American College of Neurophyscopharmacology. Archived from the original on 21 April 2008. Retrieved 2008-04-11.
  5. ISBN 978-0-444-82041-9
    .
  6. S2CID 27188133
    .
  7. PMID 10498847
    .
  8. PMID 2933009
    .
  9. PMID 30568756
    .
  10. PMID 35835867
    .
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