8β-VE2
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| Other names | 8β-Vinylestradiol; 8β-Vinylestra-1,3,5(10)-triene-3β,17β-diol |
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JSmol) | |
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8β-VE2, or 8β-vinylestradiol, also known as 8β-vinylestra-1,3,5(10)-triene-3β,17β-diol, is a
binding affinity for the ERβ over the ERα.[2]
In rodents, 8β-VE2 stimulates follicular growth and to a comparable extent as estradiol, whereas the highly ERα-selective agonist 16α-LE2 has no effect on ovarian follicle development, indicating that the ERβ and not the ERα is involved in the effects of estrogen on ovarian follicles.[2][3] In contrast, 16α-LE2 stimulates uterine weight, whereas 8β-VE2 has no effect, indicating that the ERα and not the ERβ is involved in the effects of estrogen on the uterus.[2]
Research has determined through experimental
protein synthesis, as 8β-VE2 has been found to strongly induce expression of IGF-1 in the rat levator ani muscle.[5]
See also
References
- ^ ISBN 978-1-84569-574-3.
- ^ PMID 15037755.
- ISBN 978-0-12-397769-4.
- S2CID 1774519.
- ^ S2CID 39692168.