AKAP13
A-kinase anchor protein 13 is a
Function
A-kinase anchor protein 13/Rho guanine nucleotide exchange factor 13 is
AKAP13 is a member of a group of four RhoGEF proteins known to be activated by
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins that have the common function of binding to the regulatory subunit of protein kinase A (PKA), thus confining the holoenzyme to discrete locations within the cell. The AKAP13 gene encodes a member of the AKAP family since the protein binds tightly to PKA, especially in the heart.
Alternative splicing of this gene results in at least 3 transcript variants encoding different isoforms. All three contain the Dbl oncogene homology (DH) domain plus Pleckstrin homology (PH) domain (DH/PH domain) characteristic of Rho family GEFs, while only the longer two isoforms also contain the AKAP domain.[7] Therefore, these isoforms may function as scaffolding proteins to coordinate Rho signaling and protein kinase A signaling.
Interactions
AKAP13 has been shown to
See also
- Second messenger system
- G protein-coupled receptor
- Heterotrimeric G protein
- Small GTPases
- Rho family of GTPases
- Protein kinase A
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000170776 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000066406 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ S2CID 20906586.
- PMID 1860836.
- ^ a b "Entrez Gene: AKAP13 A kinase (PRKA) anchor protein 13".
- ^ PMID 11546812.
- ^ PMID 14636890.
- ^ PMID 24183240.
- PMID 11313914.
- PMID 11358341.
- PMID 12270917.
- PMID 12672969.
- PMID 1618839.
External links
- Human AKAP13 genome location and AKAP13 gene details page in the UCSC Genome Browser.
- Overview of all the structural information available in the PDB for UniProt: Q12802 (A-kinase anchor protein 13) at the PDBe-KB.
Further reading
- Hausken ZE, Coghlan VM, Hastings CA, Reimann EM, Scott JD (September 1994). "Type II regulatory subunit (RII) of the cAMP-dependent protein kinase interaction with A-kinase anchor proteins requires isoleucines 3 and 5". The Journal of Biological Chemistry. 269 (39): 24245–51. PMID 7929081.
- Toksoz D, Williams DA (February 1994). "Novel human oncogene lbc detected by transfection with distinct homology regions to signal transduction products". Oncogene. 9 (2): 621–8. PMID 8290273.
- Sterpetti P, Hack AA, Bashar MP, Park B, Cheng SD, Knoll JH, et al. (February 1999). "Activation of the Lbc Rho exchange factor proto-oncogene by truncation of an extended C terminus that regulates transformation and targeting". Molecular and Cellular Biology. 19 (2): 1334–45. PMID 9891067.
- Sagi SA, Seasholtz TM, Kobiashvili M, Wilson BA, Toksoz D, Brown JH (May 2001). "Physical and functional interactions of Galphaq with Rho and its exchange factors". The Journal of Biological Chemistry. 276 (18): 15445–52. PMID 11278452.
- Newlon MG, Roy M, Morikis D, Carr DW, Westphal R, Scott JD, Jennings PA (April 2001). "A novel mechanism of PKA anchoring revealed by solution structures of anchoring complexes". The EMBO Journal. 20 (7): 1651–62. PMID 11285229.
- Driggers PH, Segars JH, Rubino DM (December 2001). "The proto-oncoprotein Brx activates estrogen receptor beta by a p38 mitogen-activated protein kinase pathway". The Journal of Biological Chemistry. 276 (50): 46792–7. PMID 11579095.
- Klussmann E, Edemir B, Pepperle B, Tamma G, Henn V, Klauschenz E, et al. (November 2001). "Ht31: the first protein kinase A anchoring protein to integrate protein kinase A and Rho signaling". FEBS Letters. 507 (3): 264–8. PMID 11696353.
- Tan YC, Wu H, Wang WN, Zheng Y, Wang ZX (November 2002). "Characterization of the interactions between the small GTPase RhoA and its guanine nucleotide exchange factors". Analytical Biochemistry. 310 (2): 156–62. PMID 12423633.
- Spierings E, Brickner AG, Caldwell JA, Zegveld S, Tatsis N, Blokland E, et al. (July 2003). "The minor histocompatibility antigen HA-3 arises from differential proteasome-mediated cleavage of the lymphoid blast crisis (Lbc) oncoprotein". Blood. 102 (2): 621–9. S2CID 17864975.
- Hornemann T, Kempa S, Himmel M, Hayess K, Fürst DO, Wallimann T (September 2003). "Muscle-type creatine kinase interacts with central domains of the M-band proteins myomesin and M-protein". Journal of Molecular Biology. 332 (4): 877–87. PMID 12972258.
- Chen LY, Zuraw BL, Ye RD, Pan ZK (February 2004). "A Rho exchange factor mediates fMet-Leu-Phe-induced NF-kappaB activation in human peripheral blood monocytes". The Journal of Biological Chemistry. 279 (8): 7208–12. PMID 14660653.
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