ARID5B
Ensembl | |||||||||
---|---|---|---|---|---|---|---|---|---|
UniProt | |||||||||
RefSeq (mRNA) | |||||||||
RefSeq (protein) | |||||||||
Location (UCSC) | Chr 10: 61.9 – 62.1 Mb | Chr 10: 67.93 – 68.11 Mb | |||||||
PubMed search | [3] | [4] |
View/Edit Human | View/Edit Mouse |
AT-rich interactive domain-containing protein 5B is a protein that in humans is encoded by the ARID5B gene.[5][6][7]
Alternative names for this gene include Modulator recognition factor 23.
Genomics
The gene is located on the long arm of chromosome 10 (10q21.2) on the 'plus' strand. It spans 195,261 base pairs in length. It encodes a protein of predicted length and molecular weight of 1188 amino acids and 132.375 kilodaltons respectively.
Clinical importance
Through genome wide association studies (GWAS),some of the single nucleotide polymorphisms (SNPs) located in this gene has been noticed to be significantly associated with susceptibility [8][9][10]
as well as treatment outcomes leukaemia in ethnically diverse populations.
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000150347 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000019947 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 11483573.
- PMID 11478881.
- ^ "Entrez Gene: ARID5B AT rich interactive domain 5B (MRF1-like)".
- PMID 23512250.
- PMID 19684603.
- PMID 19684604.
- PMID 22291082.
External links
- Human ARID5B genome location and ARID5B gene details page in the UCSC Genome Browser.
Further reading
- Yuan YC, Whitson RH, Liu Q, Itakura K, Chen Y (Nov 1998). "A novel DNA-binding motif shares structural homology to DNA replication and repair nucleases and polymerases". Nature Structural Biology. 5 (11): 959–64. S2CID 10099806.
- Whitson RH, Huang T, Itakura K (May 1999). "The novel Mrf-2 DNA-binding domain recognizes a five-base core sequence through major and minor-groove contacts". Biochemical and Biophysical Research Communications. 258 (2): 326–31. PMID 10329386.
- Patsialou A, Wilsker D, Moran E (2005). "DNA-binding properties of ARID family proteins". Nucleic Acids Research. 33 (1): 66–80. PMID 15640446.
- Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. S2CID 7827573.