ATP:guanido phosphotransferase family
ATP:guanido phosphotransferase catalytic domain | |||||||||
---|---|---|---|---|---|---|---|---|---|
|
ATP:guanido phosphotransferase N-terminal domain | |||||||||
---|---|---|---|---|---|---|---|---|---|
|
In molecular biology, the ATP:guanido phosphotransferase family is a family of
enzymes
belonging to this family include:
- guanidoacetate.
- Arginine kinase (EC 2.7.3.3), which catalyses the transfer of phosphate from ATP to arginine.
- Taurocyamine kinase (EC 2.7.3.4), an annelid-specific enzyme that catalyses the transfer of phosphate from ATP to taurocyamine.
- Lombricine kinase (EC 2.7.3.5), an annelid-specific enzyme that catalyses the transfer of phosphate from ATP to lombricine.
- Smc74, a cercaria-specific enzyme from Schistosoma mansoni.[1]
- Creatine kinase (EC 2.7.3.2) (CK),[3][4] which catalyses the reversible transfer of high energy phosphate from ATP to creatine, generating phosphocreatine and ADP.
Creatine kinase plays an important role in energy
highly conserved
.
ATP:guanido phosphotransferases contain a
N-terminal domain which has an all-alpha fold consisting of an irregular array of 6 short helices.[5]