Abaucin

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Abaucin
Identifiers
  • 1'-[2-[4-(trifluoromethyl)phenyl]ethyl]spiro[1H-3,1-benzoxazine-4,4'-piperidine]-2-one
JSmol)
  • C1CN(CCC12C3=CC=CC=C3NC(=O)O2)CCC4=CC=C(C=C4)C(F)(F)F
  • InChI=1S/C21H21F3N2O2/c22-21(23,24)16-7-5-15(6-8-16)9-12-26-13-10-20(11-14-26)17-3-1-2-4-18(17)25-19(27)28-20/h1-8H,9-14H2,(H,25,27)
  • Key:HIDWEYPGMLIQSN-UHFFFAOYSA-N

Abaucin (RS-102895, MLJS-21001) is a compound which has been reported to show useful activity as a narrow-spectrum

James J. Collins, and McMaster's Jonathan Stokes.[2][3][4] Its mode of action involves inhibiting lipoprotein transport. The compound had previously been reported as an antagonist of the chemokine receptor CCR2, but its antibiotic activity was not discovered during earlier research.[5][6][7][8][9]

A New York Times opinion piece by Peter Coy for Thanksgiving listed abaucin among scientific discoveries to be thankful for in 2023.[10]

See also

References

  1. S2CID 258909341
    .
  2. ^ Gallagher J (May 25, 2023). "New superbug-killing antibiotic discovered using AI". BBC News.
  3. ^ Trafton A (25 May 2023). "Using AI, scientists find a drug that could combat drug-resistant infections". MIT News. Retrieved 28 May 2023.
  4. ^ "Scientists use AI to find promising new antibiotic to fight evasive hospital superbug". McMaster University. 25 May 2023.
  5. PMID 6842505
    .
  6. PMID 10770925
    .
  7. S2CID 253752924
    .
  8. PMID 24632828
    .
  9. PMID 32150444
    .
  10. ISSN 0362-4331
    . Retrieved 2023-11-26.
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