Aleixo Muise

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Aleixo Muise
BornJune 5, 1969
NationalityCanadian
Alma mater
Known for
Scientific career
Fields
Institutions

Aleixo M. Muise FRCPC (born June 5, 1969) is a Canadian scientist, pediatrician and gastroenterologist known for contributions to the understanding of very early onset inflammatory bowel disease. He is a professor of pediatrics at the University of Toronto, a Tier 1 Canada Research Chair in pediatric inflammatory bowel disease, and a pediatric gastroenterologist at the Hospital for Sick Children.

Biography

Muise completed a Bachelor of Science degree at St. Francis Xavier University, followed by graduate studies at Carleton University and Dalhousie University.[1] His postgraduate work was with Daniela Rotin at the Hospital for Sick Children in Toronto.[1] He completed undergraduate and postgraduate training in medicine, pediatrics and gastroenterology at the University of Toronto.[1]

Muise was appointed as full professor in the departments of Pediatrics and Biochemistry and in the Institute of Medical Science at the University of Toronto in 2018.[1] He was awarded a Tier 1 Canada Research Chair in pediatric inflammatory bowel disease in 2019.[2]

Research

Muise's clinical and research program focuses on

whole exome sequencing and whole genome sequencing to identify known and novel genetic variants in children with intestinal diseases. Most notably, Muise identified a novel form of VEOIBD related to mutations in the TTC7A gene[3] and described potential treatments for this incurable disease.[4] He has uncovered the underlying genetic and functional causes of a number of diseases, including PLVAP, ARPC1B and SYK.[5][6][7]

Muise's research has allowed for appropriate, personalized treatment to be given to children with genetic forms of intestinal disease, including

IL10R that lead to risk of developing VEOIBD, and may allow for novel treatment strategies based on these genetic findings.[10]

Muise founded the interNational Early Onset Paediatric IBD Cohort Study (NEOPICS) consortium, which connects pediatric gastroenterologists and scientists internationally to identify patients with rare intestinal diseases. This has allowed for the creation of the largest repository of DNA of patients with VEOIBD.[11]

Honors

References

  1. ^ a b c d "Aleixo Muise". Hospital for Sick Children (Toronto). Retrieved May 11, 2021.
  2. ^ a b "Canada Research Chairs Spring 2019 Recipients (Cycle 2018-2)". Government of Canada. 2020-02-26. Retrieved May 12, 2021.
  3. PMID 24417819
    .
  4. PMID 31743734
    .
  5. PMID 26207260
    .
  6. PMID 28368018
    .
  7. PMID 33782605
    .
  8. ^ Picard, Andre (10 December 2012). "Bone-marrow transplant cures girl's inflammatory bowel disease". The Globe and Mail. Toronto.
  9. ^ Ubelacker, Sheryl (3 April 2017). "Toronto doctors identify new disease in children caused by defective gene". Canadian Press. Toronto.
  10. ^
    PMID 26289262
    .
  11. ^ "NEOPICS". Retrieved May 10, 2021.
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