Alexander Hoffmann (biologist)
Alexander Hoffmann | |
---|---|
Alma mater | |
Known for | Systems biology |
Scientific career | |
Institutions | |
Doctoral advisor | Robert G. Roeder |
Other academic advisors | David Baltimore |
Alexander Hoffmann is a German-American biologist. He is the director of the Institute for Quantitative and Computational Biosciences (QCBio) and the Thomas M Asher Professor of Microbiology in the Department of Microbiology, Immunology, and Molecular Genetics (MIMG) at the University of California, Los Angeles (UCLA). His research interest is the development of a predictive understanding of how cellular and molecular networks regulate immune responses.[1]
Education
Hoffmann gained his BA in Physics and Zoology at
Career
Hoffmann pursued postdoctoral research with
Hoffmann established the Signaling Systems Laboratory at
In 2010, he established the San Diego Center for Systems Biology, being awarded a "Center of Excellence" grant from the
Other roles
Hoffmann served with
Hoffmann has worked to improve equity in educational opportunities. He led educational outreach programs at Caltech (Young Engineering Science Scholars,[19] Freshman Summer Institute[20]), and served at UCSD on the committee for Equity, Diversity and Inclusion, and as chair of the Chancellor's Diversity Council, focusing on student and faculty recruitment and retention practices, and institutional change.
References
- ^ a b c "Alexander Hoffman". Signaling Systems Laboratory at the University of California Los Angeles. Retrieved 4 November 2022.
- ^ Hoffmann, A., Horikoshi, M., Wang, C. K., Schroeder, S., Weil, P.A., Roeder, R.G. 1990. Cloning of the Schizosaccharomyces pombe TFIID gene reveals a strong conservation of functional domains present in Saccharomyces cerevisiae TFIID. Genes & Development 4, pp. 1141-1148
- ^ Hoffmann, A., Sinn, E., Yamamoto, T., Wang, J., Roy, A., Horikoshi, M., Roeder, R.G. 1990. Highly conserved core domain and unique N-terminus with presumptive regulatory motifs in a human TATA factor (TFIID). Nature 346, No.6282, pp.387-390
- ^ Gasch, A., Hoffmann, A., Horikoshi, M., Roeder, R.G., Chua, N.H. 1990. Arabidopsis thaliana contains two genes for TFIID. Nature 346, No.6282, pp.390-394
- ^ Hoffmann, A., Chiang, C.-M., Oelgeschläger, T., Burley, S.K., Nakatani, Y., Roeder, R.G. 1996 A histone octamer-like structure within TFIID. Nature 380, No.6572, pp. 356-359
- ^ Hoffmann, A., Oelgeschläger, T., Roeder, R.G. 1997 Considerations of transcriptional control mechanisms: Do TFIID-core promoter complexes recapitulate nucleosome-like functions ? Proc. Natl. Acad. Sci. USA 94, pp. 8928-8935
- ^ Hoffmann, A. and Roeder, R.G. 1991. Purification of his-tagged proteins in non-denaturing conditions suggests a convenient method for protein interaction studies. Nucleic Acids Research 19, No.22, pp. 6337-6338
- ^ Nikolov, D.B., Hu, S.-H., Lin, J., Gasch, A., Hoffmann, A., Horikoshi, M., Chua, N.-H., Roeder, R.G., Burley, S.K. 1992. Crystal structure of TFIID TATA-box binding protein. Nature 360, pp. 40-46
- ^ Xie, X.-L., Kokubo, T., Cohen, S., Mirza, U.A., Hoffmann, A., Chait, B.T., Roeder, R.G., Nakatani, Y., Burley, S.K. 1996 Structural similarity between TAFs and the heterotetrameric core of the histone octamer. Nature 380, No.6572, pp. 316-322.
- ^ Hoffmann, A., Leung, T.H., Baltimore, D. 2003 Genetic analysis of NF-kB/Rel transcription factors reveals molecular specificities. EMBO J., 22, pp.5530-9.
- PMID 16623771
- ^ Hoffmann, A., Levchenko, A., Scott, M., Baltimore, D. 2002 The NF-B/IB signaling module: temporal control and selective gene activation. Science, 298, pp. 1241-1245
- PMC 2982931
- PMC 3343698
- ^ "Establishment of the BioCircuits Institute (BCI) as an Organized Research Unit at UC San Diego". adminrecords.ucsd.edu. Retrieved 1 December 2023.
- ^ "San Diego Center for Systems Biology". Retrieved 1 December 2023.
- ^ "UCLA Sets Up New Quantitative and Computational Biosciences Institute". Genome Web. Retrieved 1 December 2023.
- ^ Hoffmann, Alexander; Pevzner, Pavel; Subramaniam, Shankar. "Graduate Training Program in Bioinformatics". Retrieved 1 December 2023.
- ^ "Young Engineering and Science Scholars". Archived from the original on 2015-02-09. Retrieved 2018-10-10.
- ^ "Programs - Caltech Center for Diversity". Archived from the original on 2014-11-29. Retrieved 2014-10-04.