Rickettsia parkeri

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Rickettsia parkeri
Four photos showing skin problems, one of them taken through a microscope.
Rickettsia parkeri rickettsiosis skin lesions: A -
papulovesicular rash on back and leg; D - micrograph of biopsy
specimen
Scientific classification Edit this classification
Domain: Bacteria
Phylum: Pseudomonadota
Class: Alphaproteobacteria
Order: Rickettsiales
Family: Rickettsiaceae
Genus: Rickettsia
Species group:
Spotted fever group
Species:
R. parkeri
Binomial name
Rickettsia parkeri
Lackman et al., 1965

Rickettsia parkeri (abbreviated R. parkeri) is a

gram-negative intracellular bacterium. The organism is found in the Western Hemisphere and is transmitted via the bite of hard ticks of the genus Amblyomma. R. parkeri causes mild spotted fever disease in humans, whose most common signs and symptoms are fever, an eschar at the site of tick attachment, rash, headache, and muscle aches. Doxycycline
is the most common drug used to reduce the symptoms associated with disease.

Biology

R. parkeri is classified in the spotted fever group of the genus Rickettsia.[1][2] Genetically, its close relatives include R. africae, R. sibirica, R. conorii, R. rickettsii, R. peacockii, and R. honei.[1]

The organism has been isolated from numerous species of ticks in the genus Amblyomma: A. americanum in the United States; A. aureolatum in Brazil; A. maculatum in Mexico, Peru, and the United States; A. nodosum in Brazil; A. ovale in Brazil and Mexico; A. parvitarsum in Argentina and Chile; A. tigrinum in Argentina, Bolivia, Brazil, and Uruguay; and A. triste in Argentina, Brazil, the United States, and Uruguay.[2][3][4][5] Different ticks may carry different strains of the organism. R. parkeri sensu stricto ("in the strict sense") is found in A. maculatum and A. triste; R. parkeri strain NOD, in A. nodosum; R. parkeri strain Parvitarsum, in A. parvitarsum; and R. parkeri strain Atlantic rainforest, in A. aureolatum and A. ovale.[2]

Human infections

The first report of a confirmed human case of infection with R. parkeri was published in 2004.

Tidewater region in the eastern United States;[12] and "Rickettsia parkeri rickettsiosis" or "R. parkeri rickettsiosis."[7][12]

Epidemiology

Of all human cases documented in the medical literature, 87% were 18-64 years of age, and most cases were male.[8] Brazil, Argentina, and the United States accounted for the majority of cases in the medical literature.[8] In the United States, most of the 40 cases reported to the Centers for Disease Control and Prevention (CDC) as of 2016 became infected between the months of July and September.[13]: 5–6 

Diagnosis

The CDC recommends polymerase chain reaction (PCR) of a biopsy or swab of an eschar, or PCR of a biopsy of a rash, for diagnosis of R. parkeri infection.[13]: 27  In addition, indirect immunofluorescence antibody (IFA) assays using paired acute and convalescent sera can be used.[13]: 27 

Clinical manifestations

A 2008 study compared 12 R. parkeri cases with 208 Rocky Mountain spotted fever cases caused by R. rickettsii.[7] Although both R. parkeri and R. rickettsii caused fever, rash, myalgia, and headache, R. parkeri caused eschars and R. rickettsii did not.[7] Furthermore, the percentage of patients hospitalized was lower for R. parkeri than for R. rickettsii (33% vs 78%), and R. parkeri led to no deaths while R. rickettsii led to death in 7% of cases.[7]

A 2021 systematic review of 32 confirmed and 45 probable cases of human infection with R. parkeri determined that 94% of the confirmed cases had fever, 91% an eschar, 72% a rash, 56% headache, and 56% myalgia, with similar percentages among the probable cases.[8] The rash was most frequently described as papular or macular.[8] Among the confirmed and probable cases, the most common treatment was doxycycline, followed by tetracycline.[8] Although 9% of all the cases were hospitalized, there was a "100% rate of clinical recovery."[8]

History

In 1939, Ralph R. Parker, director of the

Rocky Mountain Laboratory, and others published a paper on "a rickettsia-like infectious agent."[7][14] The agent, found in Amblyomma maculatum ticks collected from cows in Texas, produced mild disease in guinea pigs.[7][14] In 1965, Lackman and others named the rickettsial organism R. parkeri after Parker.[2][15]

References

  1. ^
    PMID 16901827.{{cite journal}}: CS1 maint: multiple names: authors list (link
    )
  2. ^
    PMID 29439989.{{cite journal}}: CS1 maint: multiple names: authors list (link
    )
  3. PMID 19788817.{{cite journal}}: CS1 maint: multiple names: authors list (link
    )
  4. PMID 30882330.{{cite journal}}: CS1 maint: multiple names: authors list (link
    )
  5. PMID 31742525.{{cite journal}}: CS1 maint: multiple names: authors list (link
    )
  6. ^
    PMID 14999622.{{cite journal}}: CS1 maint: multiple names: authors list (link
    )
  7. ^
    PMID 18808353.{{cite journal}}: CS1 maint: multiple names: authors list (link
    )
  8. ^
    S2CID 234596034.{{cite journal}}: CS1 maint: multiple names: authors list (link
    )
  9. S2CID 246701684.{{cite journal}}: CS1 maint: multiple names: authors list (link
    )
  10. PMID 15799527
    .
  11. PMID 32748891.{{cite journal}}: CS1 maint: multiple names: authors list (link
    )
  12. ^
    PMID 21529406.{{cite journal}}: CS1 maint: multiple names: authors list (link
    )
  13. ^
    PMID 27172113.{{cite journal}}: CS1 maint: multiple names: authors list (link
    )
  14. ^
    PMID 18808353.{{cite journal}}: CS1 maint: multiple names: authors list (link
    )
  15. PMID 14318051.{{cite journal}}: CS1 maint: multiple names: authors list (link
    )

External links
Retrieved from "https://en.wikipedia.org/w/index.php?title=Rickettsia_parkeri&oldid=1197196093#Human_infections"