Angiomatoid fibrous histiocytoma
| Angiomatoid fibrous histiocytoma | |
|---|---|
 | |
| Micrograph showing an angiomatoid fibrous histiocytoma. H&E stain. |
Angiomatoid fibrous histiocytoma (AFH) is a rare soft tissue
MasterChef Junior participant Ben Watkins died from the disease at the age of 14.[1]
Pathology
It is characterized by cystic blood-filled spaces and composed of histiocyte-like cells. A lymphocytic cuff is common. It often simulates a vascular lesion, and was initially described as doing this.[2]
AFH typically has a chromosomal translocation involving the ATF1 gene -- t(12;16) FUS/ATF1 or t(12;22) EWS/ATF1.[3]
Diagnosis
![[icon]](/File:Wiki_letter_w_cropped.svg){kind=small} | This section is empty. You can help by adding to it. (December 2017) |
Treatment
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See also
- Granulomatous inflammation
- Vascular tumor
References
- ^ "Ben Watkins: US MasterChef Junior star dies aged 14". BBC News. 18 November 2020.
- PMID 228836.
- PMID 25927151.
Further to the characterization of the recurrent chromosomal rearrangements that result in the EWSR1-CREB1, t(12;22)(q13;q12) EWSR1-ATF1, and t(12;16)(q13;p11) FUS-ATF1 gene fusions, AFH is of course now established as a translocation-associated neoplasm.
External links
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