BRAT1

BRAT1
Available structures
Gene ontology
Molecular function	protein binding;
Cellular component	cytoplasm; membrane; nucleus; nucleoplasm;
Biological process	mitochondrion localization; response to ionizing radiation; cell growth; positive regulation of protein phosphorylation; cell population proliferation; cell migration; glucose metabolic process; cellular response to DNA damage stimulus; apoptotic process; positive regulation of cell growth;
	Sources:Amigo / QuickGO
	ENSG00000106009
	ENSMUSG00000000148
	Q6PJG6
	Q8C3R1
	NM_152743; NM_001350626; NM_001350627
	NM_001276287; NM_172724; NM_181066
	NP_689956; NP_001337555; NP_001337556
	NP_001263216; NP_851411
	Wikidata
View/Edit Human	View/Edit Mouse

BRCA1-associated ATM activator 1 is a protein in humans that is encoded by the BRAT1 gene.^[5]

Function

The protein encoded by this ubiquitously expressed gene interacts with the tumor suppressing

double-strand breaks that are induced by ionizing radiation and complexes with BRCA1 in the multi-protein complex BASC (BRAC1-associated genome surveillance complex). The protein encoded by this gene is thought to play a role in the DNA damage pathway regulated by BRCA1 and ATM.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000106009 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000000148 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: BRCA1-associated ATM activator 1".

External links

Human BRAT1 genome location and BRAT1 gene details page in the UCSC Genome Browser.
PDBe-KB provides an overview of all the structure information available in the PDB for Human BRCA1-associated ATM activator

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000106009 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000000148 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: BRCA1-associated ATM activator 1".

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