Betaherpesvirinae

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Betaherpesvirinae
Cytomegalovirus infection of a
pneumocyte
Virus classification Edit this classification
(unranked): Virus
Realm: Duplodnaviria
Kingdom:
Heunggongvirae
Phylum: Peploviricota
Class: Herviviricetes
Order: Herpesvirales
Family:
Orthoherpesviridae
Subfamily: Betaherpesvirinae
Genera

See text

Betaherpesvirinae is a subfamily of

sixth disease' (also known as roseola infantum or exanthem subitum); HHV-7: symptoms analogous to the 'sixth disease'.[1][2]

Genera

Betaherpesvirinae consists of the following five genera:[2]

Structure

Viruses in Betaherpesvirinae are enveloped, with icosahedral, spherical to pleomorphic, and Round geometries, and T=16 symmetry. The diameter is around 150-200 nm. Genomes are linear and non-segmented, around 140-240kb in length.[1]

Genus Structure Symmetry Capsid Genomic arrangement Genomic segmentation
Roseolovirus Spherical pleomorphic T=16 Enveloped Linear Monopartite
Cytomegalovirus Spherical pleomorphic T=16 Enveloped Linear Monopartite
Proboscivirus Spherical pleomorphic T=16 Enveloped Linear Monopartite
Muromegalovirus Spherical pleomorphic T=16 Enveloped Linear Monopartite

Life cycle

Viral replication is nuclear, and is lysogenic. Entry into the host cell is achieved by attachment of the viral glycoproteins to host receptors, which mediates endocytosis. Replication follows the dsDNA bidirectional replication model. DNA templated transcription, with some alternative splicing mechanism is the method of transcription. Translation takes place by leaky scanning. The virus exits the host cell by nuclear egress and budding. Betaherpesviruses typically have highly restricted host ranges, although essentially all mammals, reptiles, and birds are infected with at least one betaherpesvirus species. Transmission routes are transplacental, transplantation, blood transfusion, body fluids, urine, and saliva.[1]

Betaherpesvirinae establish latency (site where virus lies dormant until reactivated) in CD34+

myeloid progenitor cells and CD14+ monocytes.[3] This is different from Alphaherpesvirinae, which establish latency in neurons, and Gammaherpesvirinae, which establish latency in memory B cells.[3]

Genus Host details Tissue tropism Entry details Release details Replication site Assembly site Transmission
Roseolovirus Humans T-cells; B-cells; NK-cell; monocytes; macrophages; epithelial Glycoprotiens Budding Nucleus Nucleus Respiratory contact
Cytomegalovirus Humans; monkeys Epithelial mucosa Glycoprotiens Budding Nucleus Nucleus Urine; saliva
Proboscivirus Elephants None Glycoprotiens Budding Nucleus Nucleus Contact
Muromegalovirus Rodents Salivary glands Glycoprotiens Budding Nucleus Nucleus Contact

Human health

There are four known member species of the Betaherpesvirinae subfamily that are infectious for humans:

Human cytomegalovirus (HCMV, HHV-5) "seems to have a large impact on immune parameters in later life and may contribute to increased morbidity and eventual mortality."

exanthema subitum
, roseola infantum (rose rash of infants) or the sixth disease.

References

Wikimedia Commons has media related to Betaherpesvirinae.
Wikispecies has information related to Betaherpesvirinae.
  1. ^ a b c "Viral Zone". ExPASy. Retrieved 12 June 2015.
  2. ^ a b "Virus Taxonomy: 2020 Release". International Committee on Taxonomy of Viruses (ICTV). March 2021. Retrieved 10 May 2021.
  3. ^
    PMID 32364538
    .
  4. PMID 22481600
    .
  5. PMID 19624841
    .
  6. S2CID 31720143
    .
  7. PMID 17276363
    .

External links
Retrieved from "https://en.wikipedia.org/w/index.php?title=Betaherpesvirinae&oldid=1219025300"