Biobreeding rat
Biobreeding rat, also known as the BB or BBDP rat, is an inbred
Two T1D susceptibility genes have been identified in the BB rat. The susceptible MHC class II RT1u haplotype on chromosome 20 [2] and a null mutation in the GIMAP5 gene on chromosome 4.[3] The Gimap5 mutation results in severe T cell lymphopenia in the BB rat and is thought to contribute to T1D pathogenesis through impaired development and function and regulatory T cells.[4] Recently, 8 additional loci on rat chromosomes 1,2,3,6 (2 loci), 12 and 14 have been shown to be linked to Type 1 Diabetes in the BB rat.[5]
History
BB rats are the most extensively studied rat model of T1D. They were originally derived from a Canadian colony of outbred
Modulation of diabetes
Diabetes in BB rats can be prevented by a single injection of mycobacterial adjuvants such as complete Freund's adjuvant (FCA).[8]
See also
- NOD mice
- Type 1 Diabetes
- Autoimmunity
References
- ^ Mordes JP, Poussier P, Blankenhorn EP, Greiner DL: Rat models of type 1 diabetes: Genetics, environment and autoimmunity. Boca Raton, CRC Press, 2007
- ^ Colle, E., R.D. Guttmann, and T. Seemayer, Spontaneous diabetes mellitus syndrome in the rat. I. Association with the major histocompatibility complex. The Journal of experimental medicine, 1981. 154(4): p. 1237-42.
- ^ Poussier, P., et al., Lymphopenia and abnormal lymphocyte subsets in the "BB" rat: relationship to the diabetic syndrome. Endocrinology, 1982. 110(5): p. 1825-7.
- ^ Poussier, P., et al., Impaired post-thymic development of regulatory CD4+25+ T cells contributes to diabetes pathogenesis in BB rats. Journal of Immunology, 2005. 174(7): p. 4081-9.
- ^ Wallis RH, Wang K, Marandi L, Hsieh E, Ning T, Chao GY, Sarmiento J, Paterson AD, Poussier P.: Type 1 diabetes in the BB rat: a polygenic disease. Diabetes. 2009 Apr;58(4):1007-17. Epub 2009 Jan 23
- ^ Mordes, J.P., et al., Rat models of type 1 diabetes: genetics, environment, and autoimmunity. ILAR J, 2004. 45(3): p. 278-91.
- ^ Mordes, J.P., et al., Rat models of type 1 diabetes: genetics, environment, and autoimmunity. ILAR J, 2004. 45(3): p. 278-91.
- ^ Sadelain MW, Qin HY, Sumoski W, Parfrey N, Singh B, Rabinovitch A.
Prevention of diabetes in the BB rat by early immunotherapy using Freund's adjuvant. J Autoimmun; 1990 ; 3:671-80. PMID 2088390