Blood–brain barrier disruption
Blood–brain barrier disruption is the surgical process whereby drugs are used to create openings between cells in the blood–brain barrier.[1]
Purpose
The blood–brain barrier (BBB) is protected by a network of blood vessels and tissue that shields it from harmful substances. This protection also stops anti-cancer drugs from getting to the brain. To treat brain tumours and other brain related diseases,[2][3] blood–brain barrier disruption is needed for the anti-cancer drugs to be infused into an artery that goes to the brain.[1]
Effects
Studies have shown that blood–brain barrier disruption can cause diseases in the central nervous system.[4][5]
References
- ^ a b "Definition of blood–brain barrier disruption". www.cancer.gov. 2011-02-02. Retrieved 2023-02-09.
- S2CID 29504371.
- ^ InSightec (2023-01-18). "A Pivotal Study to Evaluate the Safety and Effectiveness of Exablate Model 4000 Using Microbubble Resonators to Temporarily Mediate Blood–brain barrier Disruption (BBBD) for Liquid Biopsy in Subjects With GlioBlastoma Brain Tumors".
{{cite journal}}: Cite journal requires|journal=(help) - S2CID 231611519.
- PMID 32484111.