Source: Wikipedia, the free encyclopedia.
Protein-coding gene in the species Homo sapiens
CCL4L2 Gene ontology
Molecular function Cellular component Biological process Sources:Amigo / QuickGO
Wikidata C-C motif chemokine 4-like is a protein that in humans is encoded by the CCL4L1 gene .[3] [4] [5] [6]
Function This gene is one of several
reference assembly contains two copies of this gene. This record represents the more centromeric gene.
[6] References External links Further reading
Menten P, Wuyts A, Van Damme J (2003). "Macrophage inflammatory protein-1". Cytokine Growth Factor Rev . 13 (6): 455–81. . Napolitano M, Modi WS, Cevario SJ, et al. (1991). "The gene encoding the Act-2 cytokine. Genomic structure, HTLV-I/Tax responsiveness of 5' upstream sequences, and chromosomal localization" . J. Biol. Chem . 266 (26): 17531–6. . Baixeras E, Roman-Roman S, Jitsukawa S, et al. (1991). "Cloning and expression of a lymphocyte activation gene (LAG-1)". Mol. Immunol . 27 (11): 1091–102. . Lipes MA, Napolitano M, Jeang KT, et al. (1989). "Identification, cloning, and characterization of an immune activation gene" . Proc. Natl. Acad. Sci. U.S.A . 85 (24): 9704–8. . Brown KD, Zurawski SM, Mosmann TR, Zurawski G (1989). "A family of small inducible proteins secreted by leukocytes are members of a new superfamily that includes leukocyte and fibroblast-derived inflammatory agents, growth factors, and indicators of various activation processes" . J. Immunol . 142 (2): 679–87. . Zipfel PF, Balke J, Irving SG, et al. (1989). "Mitogenic activation of human T cells induces two closely related genes which share structural similarities with a new family of secreted factors" . J. Immunol . 142 (5): 1582–90. . Chang HC, Reinherz EL (1989). "Isolation and characterization of a cDNA encoding a putative cytokine which is induced by stimulation via the CD2 structure on human T lymphocytes". Eur. J. Immunol . 19 (6): 1045–51. . Miller MD, Hata S, De Waal Malefyt R, Krangel MS (1989). "A novel polypeptide secreted by activated human T lymphocytes" . J. Immunol . 143 (9): 2907–16. . Lodi PJ, Garrett DS, Kuszewski J, et al. (1994). "High-resolution solution structure of the beta chemokine hMIP-1 beta by multidimensional NMR" . Science . 263 (5154): 1762–7. . Cocchi F, DeVico AL, Garzino-Demo A, et al. (1996). "Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells" . Science . 270 (5243): 1811–5. . Bernardini G, Hedrick J, Sozzani S, et al. (1998). "Identification of the CC chemokines TARC and macrophage inflammatory protein-1 beta as novel functional ligands for the CCR8 receptor". Eur. J. Immunol . 28 (2): 582–8. . Garlisi CG, Xiao H, Tian F, et al. (1999). "The assignment of chemokine-chemokine receptor pairs: TARC and MIP-1 beta are not ligands for human CC-chemokine receptor 8". Eur. J. Immunol . 29 (10): 3210–5. . Modi WS, Bergeron J, Sanford M (2001). "The human MIP-1beta chemokine is encoded by two paralogous genes, ACT-2 and LAG-1" . Immunogenetics . 53 (7): 543–9. . Guan E, Wang J, Roderiquez G, Norcross MA (2002). "Natural truncation of the chemokine MIP-1 beta /CCL4 affects receptor specificity but not anti-HIV-1 activity" . J. Biol. Chem . 277 (35): 32348–52. . Townson JR, Barcellos LF, Nibbs RJ (2002). "Gene copy number regulates the production of the human chemokine CCL3-L1" . Eur. J. Immunol . 32 (10): 3016–26. . Lu J, Honczarenko M, Sloan SR (2004). "Independent expression of the two paralogous CCL4 genes in monocytes and B lymphocytes". Immunogenetics . 55 (10): 706–11. .
PDB gallery
1hum : SOLUTION STRUCTURE OF THE CHEMOKINE HMIP-1BETA(SLASH)ACT-2 BY MULTI-DIMENSIONAL NMR: A NOVEL CHEMOKINE DIMER
1hun : SOLUTION STRUCTURE OF THE CHEMOKINE HMIP-1BETA(SLASH)ACT-2 BY MULTI-DIMENSIONAL NMR: A NOVEL CHEMOKINE DIMER
1je4 : Solution structure of the monomeric variant of the chemokine MIP-1beta
2ffk : Solution structure of the complex between poxvirus-encoded CC chemokine inhibitor vCCI and human MIP-1beta, minimized average structure
2fin : Solution Structure of the complex between poxvirus-encoded CC chemokine inhibitor vCCI and human MIP-1beta, ensemble structure
