CGK733 fraud
CGK733 was a synthetic chemical substance which was reported in 2006 to have remarkable properties in reversing cell senescence (aging).[1] However, the entire work behind the discovery of this compound has since been found to be falsified and the authors of the original reports have retracted all their claims.[2][3]
CGK733 was claimed to be an inhibitor of
The original report garnered scientific attention,[6] but was retracted in 2008.[7] The retraction states that the screen to identify CGK733 as an anti-senescence agent was not carried out; experiments exploring the cellular effects of CGK733 were misrepresented; the identification of ATM as the target of CGK733 was fabricated; a compound which was essential for ATM target validation had not been synthesized; and the chemical structure of CGK733 was misrepresented.[7]
The principal investigator, Tae Kook Kim, and several associates were consequently suspended from their positions at the
References
- PMID 18560433)
- ^ a b Dennis Normile; Jennifer Couzin (March 5, 2008). "South Korean researcher suspended over charges of scientific misconduct". Science Now. Archived from the original on 2008-03-09. Retrieved 2008-03-17.
- ^ Kenneth J. Moore (2008). "Data Duping". Chemical & Engineering News. Retrieved 2008-04-01.
- PMID 19136059.
- PMID 18347191.
- ^ Sarah Everts (2006). "Aging Cells Get New Lease On Life - Small molecule is found to extend lifetime of mammalian cells". Chemical & Engineering News. Retrieved 2007-03-09.
- ^ PMID 18560433.