CHIR99021

Add links
Source: Wikipedia, the free encyclopedia.
CHIR99021
Names
IUPAC name
6-((2-((4-(2,4-Dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)pyrimidin-2-yl)amino)ethyl)amino)nicotinonitrile
Identifiers
3D model (
JSmol
)
ECHA InfoCard
 100.236.922 Edit this at Wikidata
UNII
  • InChI=1S/C22H18Cl2N8/c1-13-10-29-21(31-13)17-12-30-22(32-20(17)16-4-3-15(23)8-18(16)24)27-7-6-26-19-5-2-14(9-25)11-28-19/h2-5,8,10-12H,6-7H2,1H3,(H,26,28)(H,29,31)(H,27,30,32)
    Key: AQGNHMOJWBZFQQ-UHFFFAOYSA-N
  • N#CC1=CN=C(NCCNC2=NC=C(C3=NC(C)=CN3)C(C4=CC=C(Cl)C=C4Cl)=N2)C=C1
Properties
C22H18Cl2N8
Molar mass 465.34 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

CHIR99021 is a chemical compound which acts as an inhibitor of the enzyme GSK-3.[1] It has proved useful for applications in molecular biology involving the transformation of one cell type to another.[2][3]

A mixture of CHIR99021 and

valproic acid (FX-322) is claimed to increase the proliferation of inner ear stem cells, potentially allowing regrowth of the hair cells which are important for hearing, and are lost through chronic exposure to loud noises or as part of the aging process.[4][5][6]

See also

References

  1. PMID 23658955
    .
  2. PMID 26665937
    .
  3. PMID 29739872
    .
  4. ^ US 2017226477, Karp JM, Yin X, Succi MD, Langer RS, "Compositions and methods for epithelial stem cell expansion and culture", published 10 August 2017, assigned to Massachusetts Institute of Technology and The Brigham and Women's Hospital, Inc. 
  5. ^ US 11033546, Loose C, McLean W, Harrison M, Jirousek MR, "Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using a GSK3 inhibitor", published 15 June 2021, assigned to Frequency Therapeutics Inc. 
  6. PMID 28228258
    .
Retrieved from "https://en.wikipedia.org/w/index.php?title=CHIR99021&oldid=1080758389"