CLC (gene)

CLC
	Gene ontology
Molecular function	cysteine-type endopeptidase activity involved in apoptotic process; lysophospholipase activity; protein binding; carbohydrate binding; identical protein binding;
Cellular component	cytoplasm; cytosol; collagen-containing extracellular matrix;
Biological process	multicellular organism development; T cell apoptotic process; regulation of T cell cytokine production; regulation of activated T cell proliferation; regulation of T cell anergy;
	Sources:Amigo / QuickGO

Ensembl


ENSG00000105205


n/a

UniProt


Q05315


n/a

RefSeq (mRNA)


NM_001828


n/a

RefSeq (protein)


NP_001819


n/a

Location (UCSC)

Chr 19: 39.73 – 39.74 Mb

n/a

PubMed search

^[2]

n/a

Wikidata

View/Edit Human

Galectin-10 is an enzyme that in humans is encoded by the CLC gene.^[3]^[4]

beta-galactoside binding proteins. It may be associated with inflammation and some myeloid leukemias.^[4]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000105205 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
PMID 1577491
.

^ ^a ^b "CLC Charcot-Leyden crystal galectin [ Homo sapiens (human) ]".

External links

Human CLC genome location and CLC gene details page in the UCSC Genome Browser.

Further reading

Gleich GJ, Loegering DA, Mann KG, Maldonado JE (1976). "Comparative properties of the Charcot-Leyden crystal protein and the major basic protein from human eosinophils". J. Clin. Invest. 57 (3): 633–40.
PMID 942977
.

Golightly LM, Thomas LL, Dvorak AM, Ackerman SJ (1992). "Charcot-Leyden crystal protein in the degranulation and recovery of activated basophils". J. Leukoc. Biol. 51 (4): 386–92.
S2CID 24236041
.

Dvorak AM, Weller PF, Monahan-Earley RA, et al. (1990). "Ultrastructural localization of Charcot-Leyden crystal protein (lysophospholipase) and peroxidase in macrophages, eosinophils, and extracellular matrix of the skin in the hypereosinophilic syndrome". Lab. Invest. 62 (5): 590–607.
PMID 2160562
.

Dvorak AM, Letourneau L, Weller PF, Ackerman SJ (1990). "Ultrastructural localization of Charcot-Leyden crystal protein (lysophospholipase) to intracytoplasmic crystals in tumor cells of primary solid and papillary epithelial neoplasm of the pancreas". Lab. Invest. 62 (5): 608–15.
PMID 2160563
.

Dvorak AM, Ackerman SJ (1989). "Ultrastructural localization of the Charcot-Leyden crystal protein (lysophospholipase) to granules and intragranular crystals in mature human basophils". Lab. Invest. 60 (4): 557–67.
PMID 2709814
.

Sieker LC, Turley S, Le Trong I, et al. (1989). "Crystallographic characterization of human eosinophil Charcot-Leyden crystals". J. Mol. Biol. 204 (2): 489–91.
PMID 3221396
.

Weller PF, Bach D, Austen KF (1982). "Human eosinophil lysophospholipase: the sole protein component of Charcot-Leyden crystals". J. Immunol. 128 (3): 1346–9.
PMID 6173432
.

Weller PF, Bach DS, Austen KF (1985). "Biochemical characterization of human eosinophil Charcot-Leyden crystal protein (lysophospholipase)". J. Biol. Chem. 259 (24): 15100–5.
PMID 6511787
.

Gomolin HI, Yamaguchi Y, Paulpillai AV, et al. (1993). "Human eosinophil Charcot-Leyden crystal protein: cloning and characterization of a lysophospholipase gene promoter". Blood. 82 (6): 1868–74.
PMID 8400237
.

Ackerman SJ, Corrette SE, Rosenberg HF, et al. (1993). "Molecular cloning and characterization of human eosinophil Charcot-Leyden crystal protein (lysophospholipase). Similarities to IgE binding proteins and the S-type animal lectin superfamily". J. Immunol. 150 (2): 456–68.
PMID 8419478
.

Leonidas DD, Elbert BL, Zhou Z, et al. (1996). "Crystal structure of human Charcot-Leyden crystal protein, an eosinophil lysophospholipase, identifies it as a new member of the carbohydrate-binding family of galectins". Structure. 3 (12): 1379–93.
PMID 8747464
.

Dyer KD, Handen JS, Rosenberg HF (1997). "The genomic structure of the human Charcot-Leyden crystal protein gene is analogous to those of the galectin genes". Genomics. 40 (2): 217–21.
PMID 9119387
.

Swaminathan GJ, Leonidas DD, Savage MP, et al. (1999). "Selective recognition of mannose by the human eosinophil Charcot-Leyden crystal protein (galectin-10): a crystallographic study at 1.8 A resolution". Biochemistry. 38 (42): 13837–43.
PMID 10529229
.

Larramendy ML, Niini T, Elonen E, et al. (2003). "Overexpression of translocation-associated fusion genes of FGFRI, MYC, NPMI, and DEK, but absence of the translocations in acute myeloid leukemia. A microarray analysis". Haematologica. 87 (6): 569–77.
PMID 12031912
.

Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903.
PMID 12477932
.

Abedin MJ, Kashio Y, Seki M, et al. (2003). "Potential roles of galectins in myeloid differentiation into three different lineages". J. Leukoc. Biol. 73 (5): 650–6.
S2CID 21337581
.

Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35.
PMID 15057824
.

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7.
PMID 15489334
.

Nielsen K, Heegaard S, Vorum H, et al. (2005). "Altered expression of CLC, DSG3, EMP3, S100A2, and SLPI in corneal epithelium from keratoconus patients". Cornea. 24 (6): 661–8.
S2CID 21026845
.

v
t
e
PDB gallery

1g86: CHARCOT-LEYDEN CRYSTAL PROTEIN/N-ETHYLMALEIMIDE COMPLEX

1hdk: CHARCOT-LEYDEN CRYSTAL PROTEIN - PCMBS COMPLEX

1lcl: CHARCOT-LEYDEN CRYSTAL PROTEIN

1qkq: CHARCOT-LEYDEN CRYSTAL PROTEIN - MANNOSE COMPLEX

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.
v
t
e

Retrieved from "https://en.wikipedia.org/w/index.php?title=CLC_(gene)&oldid=1199279695"

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000105205 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1577491-3] PMID 1577491
.

[entrez-4] "CLC Charcot-Leyden crystal galectin [ Homo sapiens (human) ]".

[2]

[3]

[4]

See also

References

External links

Further reading