COX18, cytochrome c oxidase assembly factor
COX18 | |||
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Identifiers | |||
Gene ontology | |||
Molecular function | |||
Cellular component | |||
Biological process | |||
Sources:Amigo / QuickGO |
Ensembl | |||||||||
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UniProt | |||||||||
RefSeq (mRNA) | |||||||||
RefSeq (protein) | |||||||||
Location (UCSC) | Chr 4: 73.05 – 73.07 Mb | Chr 5: 90.36 – 90.37 Mb | |||||||
PubMed search | [3] | [4] |
View/Edit Human | View/Edit Mouse |
COX18, cytochrome c oxidase assembly factor is a protein that in humans is encoded by the COX18 gene. [5]
Function
This gene encodes a cytochrome c oxidase assembly protein. The encoded protein is essential for integral membrane protein insertion into the mitochondrial inner membrane. It is also required for cytochrome c oxidase assembly and activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014].
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000163626 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035505 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: COX18, cytochrome c oxidase assembly factor". Retrieved 2017-12-11.
Further reading
- Sacconi S, Trevisson E, Pistollato F, Baldoin MC, Rezzonico R, Bourget I, Desnuelle C, Tenconi R, Basso G, DiMauro S, Salviati L (2005). "hCOX18 and hCOX19: two human genes involved in cytochrome c oxidase assembly". Biochem. Biophys. Res. Commun. 337 (3): 832–9. PMID 16212937.
- Sacconi S, Salviati L, Trevisson E (2009). "Mutation analysis of COX18 in 29 patients with isolated cytochrome c oxidase deficiency". J. Hum. Genet. 54 (7): 419–21. PMID 19373256.
- Karasik D, Hsu YH, Zhou Y, Cupples LA, Kiel DP, Demissie S (2010). "Genome-wide pleiotropy of osteoporosis-related phenotypes: the Framingham Study". J. Bone Miner. Res. 25 (7): 1555–63. PMID 20200953.
- Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. PMID 20379614.
- Zhang X, Yang H, Lee JJ, Kim E, Lippman SM, Khuri FR, Spitz MR, Lotan R, Hong WK, Wu X (2010). "MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer". Carcinogenesis. 31 (12): 2118–23. PMID 20819778.
- Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ (2010). "Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression". PLOS ONE. 5 (9): e12862. PMID 20877624.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.