Calcimimetic
A calcimimetic is a
In the treatment of SHPT patients on dialysis calcimimetics does not appear to affect the risk of early death.[3] It does decrease the need for a parathyroidectomy but caused more issues with low blood calcium levels and vomiting.[3]
Cinacalcet was the first calcimimetic to be approved. Cinacalcet mimics calcium at the parathyroid hormone receptor. This binding will increase the sensitivity of calcium-sensing receptors (CaSR) on the parathyroid gland. As a result of the receptor "thinking" there is sufficient calcium, parathyroid hormone (PTH) secretion will be reduced. Lower calcium levels will be seen as well.
On August 25, 2015
Calcimimetics can be used concomitantly with vitamin D therapy.
Calcimimetic use can have
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