Carotegrast methyl
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Trade names | Carogra |
Other names | AJM 300 |
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Formula | C28H26Cl2N4O5 |
Molar mass | 569.44 g·mol−1 |
Carotegrast methyl (trade name Carogra) is a drug used for the treatment of ulcerative colitis.[1]
Carotegrast methyl is a
oral bioavailability, is hydrolyzed to a carboxylic acid, carotegrast, by the enzyme carboxylesterase 1 in the liver.[2] Carotegrast is an α4-integrin antagonist which prevents the chronic inflammation affecting the gastrointestinal tract in individuals with ulcerative colitis.[3]
Carotegrast methyl received approval in Japan in March 2022 for the treatment of moderate ulcerative colitis in patients who had inadequate response to mesalazine.[4]
References
- ^ "Carotegrast methyl - EA Pharma". Adis Insight.
- PMID 31965548.
- S2CID 247847704.
- S2CID 249854654.