Cdx protein family
The Cdx protein family is a group of the
hematopoiesis in vertebrates, and are also involved in the development of some types of gastrointestinal cancers and leukemias.[2]
Cdx proteins
Humans have three genes (CDX1, CDX2, and CDX4) that encode the caudal proteins:[2]
- Cdx1 protein
- Cdx2 protein
- Cdx4 protein
The human Cdx2 family protein has 94% identity with the mouse Cdx2 and the hamster Cdx3.[3]
Cdx proteins and regulation of Hox gene expression
Cdx proteins are key regulators of
promoters.[4]
Expression in mouse embryo
Cdx2 expression begins at 3.5 days and is confined to the
trophectoderm, being absent from the inner cell mass. From 8.5 days, Cdx2 begins to be expressed in embryonic tissues, principally in the posterior part of the gut from its earliest formation.[5]