Centrilobular necrosis
| Centrilobular necrosis | |
|---|---|
| Other names | Central lobular necrosis, CN |
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| Histopathology of shock liver (intermediate magnification), showing centrilobular necrosis but viable periportal hepatocytes. | |
Centrilobular necrosis (CN) is a nonspecific
acetaminophen (paracetamol),[1] thioacetamide, tetrachloride,[2] cardiac hepatopathy due to acute right sided cardiac failure, and congestive hepatic injury in veno‐occlusive disease,[3] or hypoxic injury due to ischemia.[2] Centrilobular necrosis can also be found in those with autoimmune hepatitis.[4] Centrilobular necrosis is characterized by necrotic hepatocytes completely encircling the central vein.[5]
Outlook
After a single or brief exposure to a toxicant, hepatocytes that have suffered centrilobular necrosis typically heal quickly; the liver can regain its normal appearance under a microscope in about a week. Nevertheless, fibrosis, which may be slight, occurs in the previously necrotic zone surrounding the central vein when regeneration replaces the necrotic hepatocytes if sinusoidal cells and the normal scaffolding are destroyed.[5]
See also
References
- PMID 14550746.
- ^ PMID 8200545.
- PMID 12540790.
- PMID 16505273.
- ^ ISBN 9780080919324.
Further reading
- Krishna, Murli (2017). "Patterns of necrosis in liver disease". Clinical Liver Disease. 10 (2). Ovid Technologies (Wolters Kluwer Health): 53–56. PMID 30992760.
- Misdraji, Joseph; Thiim, Michael; Graeme-Cook, Fiona M (2004). "Autoimmune Hepatitis With Centrilobular Necrosis". The American Journal of Surgical Pathology. 28 (4). Ovid Technologies (Wolters Kluwer Health): 471–478. S2CID 20808570.