Coronary flow reserve
Coronary flow reserve (CFR) is the maximum increase in blood flow through the coronary arteries above the normal resting volume.[1] Its measurement is often used in medicine to assist in the treatment of conditions affecting the coronary arteries and to determine the efficacy of treatments used.
Overview
When demand for oxygen in the
arterioles
) of the coronary artery that penetrate the myocardium, rather than those on the surface of the heart.
[1]
Measurement
Coronary flow reserve can be measured through a variety of methods, including digital subtraction
cineangiography with coronary catheterization,[4] doppler echocardiography,[5] and positron emission tomography (PET).[6]
Medical implications
Coronary flow reserve is used in diagnostics and treatment of patients with conditions such as
vasodilators are used to allow sufficient blood to flow past a stenosis
, for example, and the measurement of CFR enables the efficacy of such interventions to be measured.
Anderson-Fabry disease, there is evidence to suggest that CFR can be reduced.[5]
When coronary flow reserve is used in medicine, it is often expressed with a numerical value, which is formed by dividing the maximal coronary blood flow by resting blood flow. This allows for an objective view, which can aid diagnosis and treatment.[8]
See also
- Coronary artery
- Coronary circulation
References
- ^ a b Radó, Julia; Forster, Tamás (2001). "The significance of coronary flow reserve in chest pain syndromes" (PDF). Echo in Context. Archived from the original (PDF) on 11 June 2012.
- ^ Klabunde, Richard E. (28 March 2014). "Critical Stenosis". Cardiovascular Physiology Concepts. Archived from the original on 30 June 2014.
- ^ PMID 8280515.
- PMID 2529120.
- ^ PMID 15857518.
- S2CID 218465204.
- PMID 7897114.
- PMID 2144799.