Crystal Mackall

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Crystal Mackall
Pediatric oncology
T cell homeostasis[1]
InstitutionsStanford University
National Cancer Institute
National Institutes of Health
Websiteprofiles.stanford.edu/crystal-mackall

Crystal L. Mackall (born August 21, 1960) is an American physician and immunologist. She is currently the Ernest and Amelia Gallo Family Professor of Pediatrics and Medicine at Stanford University.[1][2] She is the founding director of the Stanford Center for Cancer Cell Therapy.

Education and early career

Mackall grew up in

pediatric oncology, where she began to focus on immunotherapy for cancer.[4][5]  She remained at National Institutes of Health until 2016, eventually serving as the Chief of the Pediatric Oncology Branch.[6]  She moved to the Stanford University School of Medicine in 2016.[6]  She is Board Certified in Internal Medicine, Pediatrics, and Pediatric Hematology/Oncology.[7][8]

Research

Mackall has pioneered

CAR T cells) therapies for childhood leukemia and also developed a CAR targeting CD22 that is active in this disease and has received Breakthrough Therapy Designation from the US FDA for treatment of CAR19 refractory B-ALL.[10][11] The CD22-CAR developed by Mackall's team is also active in large B cell lymphoma[12] and has received Breakthrough Therapy Designation from the US FDA for this indication. Working with the Monje lab at Stanford, Mackall developed a GD2-CAR that showed activity in preclinical models of diffuse midline glioma, which are lethal brain tumor occurring primarily in children and young adults,[13] and her group demonstrated that intracerebroventricular delivery of CAR T cells is more potent for treatment of brain tumors in mice than intravenous delivery.[14] Mackall and Monje are leading a clinical trial of GD2-CAR for diffuse midline gliomas, given intravenously and intracerebroventricularly, that has shown clinical activity.[15]

Mackall has elucidated fundamental biology related to T cells, with a focus on T cell exhaustion, demonstrating that cJUN overexpression prevents T cell exhaustion

chimeric antigen receptor T cell (CAR-T) to identify B-cell prolymphocytic leukemia and B-cell lymphoma.[30][31] In 2022, Mackall was awarded $11.9 million from the California Institute of Regenerative Medicine to lead a clinical trial using T cells engineered to express GD2-CAR T cells for treatment of diffuse midline gliomas.[32]

Mackall holds a number of patents relating to

Cancer Today
.

Awards and honors

Personal life

She identifies as LGBT and is married to Catherine L. Salem MD. The two have two sons, Theo Salem-Mackall and Zachary Salem-Mackall.[42]

References

  1. ^ a b Crystal Mackall publications indexed by Google Scholar Edit this at Wikidata
  2. PMID 25319501. Closed access icon
  3. ^ a b "Crystal L. Mackall, MD". aacr.org. Archived from the original on 2019-06-17. Retrieved 2019-06-17.
  4. ^ "Crystal L. Mackall, MD". aacr.org. Archived from the original on 2019-06-17. Retrieved 2019-06-17. [verification needed]
  5. ^ "Crystal Mackall". stanfordhealthcare.org. Archived from the original on 2019-06-17. Retrieved 2019-06-17. [verification needed]
  6. ^ a b "Crystal Mackall, MD". parkerici.org. Parker Institute for Cancer Immunotherapy. Retrieved 2019-06-17. [verification needed]
  7. ^ "Crystal Mackall". stanfordhealthcare.org. Archived from the original on 2019-06-17. Retrieved 2019-06-17.
  8. ^ a b "Crystal Mackall, MD". parkerici.org. Parker Institute for Cancer Immunotherapy. Retrieved 2019-06-17.
  9. ^ "Immunotherapy Expert Crystal Mackall, MD, Joins Stanford Medicine Faculty - The ASCO Post". ascopost.com. Retrieved 2019-06-17.
  10. PMID 29155426
    .
  11. ^ "FDA grants breakthrough therapy designation for new CAR T-cell therapy for B-cell acute lymphoblastic leukemia". National Cancer Institute at the National Institutes of Health. September 10, 2019.
  12. PMID 33512414
    .
  13. PMID 29662203
    .
  14. PMID 32341579
    .
  15. PMID 35130560
    .
  16. PMID 31802004
    .
  17. ^ "Pioneering Transformative T-Cell Therapies". Lyell. Retrieved 2022-12-30.
  18. PMID 33795428
    .
  19. PMID 30814055
    .
  20. S2CID 253458258
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  21. S2CID 24773329
    .
  22. PMID 18676758
    .
  23. PMID 26823601
    .
  24. PMID 20068111
    .
  25. PMID 18573906
    .
  26. PMID 26534966
    .
  27. PMID 32192573
    .
  28. PMID 21896345
    .
  29. PMID 25452614
    .
  30. ^ a b "Mackall awarded $11.9 million for anti-leukemia clinical trial". med.stanford.edu. 20 November 2017. Retrieved 2019-06-17.
  31. PMID 34312556
    .
  32. ^ cirm_2.0 (2022-12-30). "Phase 1 Clinical Trial of Autologous GD2 Chimeric Antigen Receptor T Cells for Diffuse Intrinsic Pontine Gliomas and Spinal Diffuse Midline Glioma". California's Stem Cell Agency. Retrieved 2022-12-30.{{cite web}}: CS1 maint: numeric names: authors list (link)
  33. ^ "Crystal Mackall's Profile | Stanford Profiles". profiles.stanford.edu. Retrieved 2020-10-18.
  34. ^ "Lila and Murray Gruber Memorial Cancer Research Award and Lectureship". www.aad.org. Retrieved 2020-10-18.
  35. ^ "Ludwig Cancer Research". Retrieved 2022-12-30.
  36. ^ "AACR to Recognize the St. Baldrick's Foundation-Stand Up To Cancer Pediatric Cancer Dream Team with 2021 Team Science Award". American Association for Cancer Research (AACR). Retrieved 2022-12-30.
  37. ^ "SITC Smalley Award 2021 Recipient | Richard V. Smalley, MD Memorial Award". www.sitcancer.org. Retrieved 2022-12-30.
  38. S2CID 243534420
    . Retrieved 2022-12-30.
  39. ^ "AACR Announces Fellows of the AACR Academy Class of 2022". American Association for Cancer Research (AACR). Retrieved 2022-12-30.
  40. ^ Saunders, Cindy (2022-08-30). "SFA Honors Crystal L. Mackall with 2022 Nobility in Science Award". Sarcoma Foundation of America. Retrieved 2022-12-30.
  41. ^ "Six professors elected to the National Academy of Medicine". News Center (in Samoan). 20 October 2021. Retrieved 2022-12-30.
  42. ^ "+OUTlist". Stanford Medicine. Retrieved 2020-10-18.
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