Debus–Radziszewski imidazole synthesis
| Debus–Radziszewski imidazole synthesis | |
|---|---|
| Named after | Heinrich Debus ]
Bronisław Leonard Radziszewski |
| Reaction type | Ring forming reaction |
The Debus–Radziszewski imidazole synthesis is a
multicomponent reaction
.
The reaction can be viewed as occurring in two stages. In the first stage, the dicarbonyl and two ammonia molecules condense with the two carbonyl groups to give a diimine:
In the second stage, this diimine condenses with the aldehyde:
However, the actual reaction mechanism is not certain.[2][3]
This reaction is named after
A modification of this general method, where one equivalent of ammonia is replaced by an amine, affords N-substituted imidazoles in good yields.[3]
This reaction has been applied to the synthesis of a range of 1,3-dialkylimidazolium ionic liquids by using various readily available alkylamines.[6]
References
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- ^ PMC 9054310.