Donald E. Ingber
Donald E. Ingber | |
---|---|
![]() Ingber in 2010 | |
Born | 1956 |
Academic background | |
Education | Yale College and Yale Graduate School of Arts and Sciences |
Academic work | |
Institutions | Royal Marsden Hospital Harvard University |
Notable students | Samira Musah Javier G. Fernandez |
Donald E. Ingber (born 1956)[
Ingber is a founder of the emerging fields of
Ingber has been scientific founder of five companies: Neomorphics, Inc.,[3] a tissue engineering startup which led to clinical products through subsequent acquisitions (Advanced Tissue Sciences Inc.); Tensegra, Inc. (formerly known as Molecular Geodesics, Inc.,)[4] which 3D-printed medical devices; and most recently, Emulate, Inc.,[5] which formed to commercialize human "organs-on-chips" that accelerate drug development, detect toxicities and advance personalized medicine by replacing animal testing; Boa Biomedical, Inc. (originally known as Opsonix, Inc.),[6] which aims to reduce deaths due to sepsis and blood infections by removing pathogens from the blood; and FreeFlow Medical Devices, LLC, which develops special coatings for medical devices to eliminate the formation of blood clots and biofilms on materials.
Education and academic research
Ingber grew up in East Meadow, New York.[7] He received a combined B.A./M.A. in molecular biophysics and biochemistry from Yale College and Yale Graduate School of Arts and Sciences in 1977; an M.Phil. in cell biology from Yale Graduate School of Arts and Sciences in 1981; and a combined M.D./Ph.D. from Yale School of Medicine and Yale Graduate School of Arts and Sciences in 1984.[citation needed] At Yale, he carried out undergraduate research on DNA repair with Paul Howard-Flanders,[8] and on cancer metastasis with Alan Sartorelli.
Ingber worked on development of cancer therapeutics[citation needed] with Kenneth Harrap at the Royal Cancer Hospital/Royal Marsden Hospital in England, with support from a Bates Traveling Fellowship. He carried out his Ph.D. dissertation research under the direction of Dr. James Jamieson in the department of cell biology,[9] and his advisory committee included George Palade, Elizabeth Hay and Joseph Madri. From 1984 to 1986 he completed his training as an Anna Fuller Postdoctoral Fellow[10] under the mentorship of Dr. Judah Folkman in the Surgical Research Laboratory at Boston Children's Hospital and Harvard Medical School.[11][12]
Scientific career
Appointments
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- In 1986, Ingber became an instructor in pathology at Harvard Medical School, as well as a research associate in surgery at Boston Children's Hospital and in pathology at Brigham and Women's Hospital[citation needed]
- In 1993, appointed a research associate[citation needed] in pathology at Boston Children's Hospital
- In 1999, promoted to Professor[citation needed] of Pathology at Harvard Medical School
- In 2002, appointed a senior associate[citation needed] in the Vascular Biology Program at Boston Children's Hospital
- In 2004, Ingber became the first incumbent[citation needed] of the Judah Folkman Professorship of Vascular Biology at Harvard Medical School. As of December 2019, he currently holds this position[citation needed].
- In 2008, appointed as Professor[Harvard School of Engineering and Applied Sciences. As of December 2019, he currently holds this position[citation needed].
- In 2009, appointed as the Founding Director of the Wyss Institute for Biologically Inspired Engineering at Harvard University.[13] As of 2020, he currently holds this position.[14]
- In 2018, appointed to Friedrich Merz Guest Professorship at Goethe University.[15]
Significant contributions
![](http://upload.wikimedia.org/wikipedia/commons/thumb/0/0f/Donald_Ingber_2010.jpg/220px-Donald_Ingber_2010.jpg)
Ingber is best known for his discovery of the role mechanical forces play in developmental control and in cancer formation, and for his application of these principles to develop bioinspired medical devices, nanotechnologies, and therapeutics. Ingber's early scientific work led to the discovery that
Ingber's work on tensegrity led him to propose that mechanical forces play as important a role in biological control as chemicals and genes do,[18] and to investigate the molecular mechanism by which cells convert mechanical signals into changes in intracellular biochemistry and gene expression, a process known as "mechanotransduction."[19] Ingber determined that living cells use tensegrity architecture to stabilize their shape and cytoskeleton, that cellular integrins function as mechanosensors on the cell surface, and that cytoskeletal tension (or "prestress," which is central to the stability of tensegrity structures) is a fundamental regulator of many cellular responses to mechanical cues.[20] Ingber's tensegrity theory also led to the prediction in the early 1980s that changes in extracellular matrix structure and mechanics play a fundamental role in tissue and organ development, and that deregulation of this form of developmental control can promote cancer formation.[21]
Ingber's contributions in translational medicine include discovery of one of the first angiogenesis inhibitor compounds (TNP-470)
One of his more recent innovations is the creation of tiny, complex, three-dimensional models of living human organs, known as "
Other new technologies from Ingber's lab include development of a fully biodegradable plastic alternative inspired by natural cuticle material found in shrimp shells and insect exoskeletons, known as “Shrilk”;[37] a mechanically activated nanotherapeutic that selectively directs clot-busting drugs to sites of vascular occlusion while minimizing unintended bleeding;[38] an siRNA nanoparticle therapy that prevents breast cancer progression;[39] a dialysis-like sepsis device that cleanses blood of all infectious pathogens, fungi and toxins without requiring prior identification;[40] a surface coating for medical materials and devices that prevents clot formation and bacteria accumulation that reduces the need for use of conventional anticoagulant drugs that frequently result in life-threatening side effects,[26] and a computational approach to diagnostics and therapeutics that incorporates both animation and molecular modeling software to virtually develop and test potential drugs designed to fit precisely into their targets’ molecular structures.[41]
Leadership and public service
Earlier in his career, Ingber helped to bridge Harvard University, its affiliated hospitals, and the
In 2009, Ingber was named Founding Director[
Ingber is a member of the
Ingber also has served as a consultant[citation needed] to numerous companies in the pharmaceutical, biotechnology, and cosmetics industries, including Merck, Roche, Astrazeneca, Biogen, Chanel, and L’Oreal, among others. He currently chairs[citation needed] the Scientific Advisory Boards of Emulate, Inc. and Boa Biomedical, Inc.
He is an advisory board member for Integrative Biology.[47]
Awards
Ingber has received numerous awards and distinctions, including:
- 2021: Elected a member of the National Academy of Engineering for interdisciplinary contributions to mechanobiology and microsystems engineering, and leadership in biologically inspired engineering.[48]
- 2018: Named to the Highly Cited Researchers List 2006–2016 by Clarivate Analytics.[49]
- 2017: Founder's Award from the Biophysical Society.[50]
- 2016: Elected to the American Academy of Arts and Sciences, and received the Shu Chien Award from the Biomedical Engineering Society,[51] Pioneer Award from the University of Pittsburgh,[52] and Max Tishler Lecture Award from Tufts University.[53]
- 2015: Elected to the National Academy of Inventors, and won Product Design and Best Design of the Year Awards from London Design Museum for Organs-on-Chips, named Leading Global Thinker of 2015 by Foreign Policy Magazine.[54]
- 2014: Delivered the Graeme Clark Oration in Melbourne, Australia to an audience of over 1,400.[55][56]
- 2013: Received the NC3Rs 3Rs Prize from the UK's National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs),[57] and was named an honorary member of the Society of Toxicology for his work on Organs-on-Chips.[58]
- 2012: Elected to the
- 2011: Inducted into the American Institute for Medical and Biological Engineering's College of Fellows[61] and received the Holst Medal.[62]
- 2010: Received the Lifetime Achievement Award from the Society for In Vitro Biology[63] and the Rous-Whipple Award from the American Society for Investigative Pathology.[64]
- 2009: Received the Pritzker Award from the Biomedical Engineering Society.[65]
- 2009–2014: Received a Breast Cancer Innovator Award[citation needed] from the Department of Defense.
- 2005: Received the Talbot Medal[citation needed] in Theoretical and Applied Mechanics from University of Illinois Urbana-Champaign..
- 2002: Named to Esquire's list[citation needed] of the world's "Best and Brightest".
- 1991 to 1996: Recipient of an American Cancer Society Faculty Research Award.[66]
Ingber has also been named to multiple Who's Who lists for his diverse contributions including: Science and Engineering (1991), America (1994), the World (1997), Medicine and Healthcare (1999), Business Leaders and Professionals—Honors Edition (2007), and was honored with the Albert Nelson Marquis Lifetime Achievement Award in 2018.[67]
Art and design exhibitions
Ingber collaborates internationally with artists, architects, and designers, as well as scientists, physicians, engineers, and the public. Examples of his involvement in the art/design community include:
- 2019: Guest curator[citation needed] of Bio-Futurism Exhibition and contributor to the Triennial Exhibition at Cooper-Hewitt Smithsonian Design Museum, New York; Organ Chips displayed at Barbican Centre London and Pompidou Centre Paris.
- 2018: Organ Chips displayed[citation needed] in Biodesign Exhibition at the Rhode Island School of Design, Providence, RI.
- 2017: Co-produced short film “The Beginning”[68] to entertain and educate the public about molecular biology down to the atomic scale of precision.
- 2016: Cellular Tensegrity Models, Organ Chips, and Shrilk exhibited at the Martin Gropius-Bau Museum, Berlin; Organ Chips displayed at the Holon Design Museum, Israel and King Abdulaziz Center for World Culture, Saudi Arabia[citation needed].
- 2015: Artificial biospleen prototype exhibited at the National Museum of Health and Medicine (NMHM); Organ Chips exhibited at the Museum of Modern Art (MoMA) in New York, displayed at Le Laboratoire Cambridge in Cambridge, Massachusetts, and named winner of the Design of the Year Award by the Design Museum in London;[69] Shrilk displayed at the Booth Museum of Natural history in Brighton, UK.
- 2015: Human Organs-on-Chips exhibited at the Museum of Modern Art (MoMA) in New York; displayed at Le Laboratoire Cambridge in Cambridge, Massachusetts; and selected as a finalist by the Design Museum in London for the Design of the Year Award[citation needed].
- 2011: Human Lung-on-a-Chip selected an INDEX Design for Life Award finalist and included in the INDEX: Award 2011 Exhibition in Copenhagen[citation needed].
- 2010: Tensegrity multimedia exhibition displayed at Le Laboratoire in Paris; lecture presentation on tensegrity and nanobiotechnology at the Boston Museum of Science[citation needed].
- 2005: Tensegrity multimedia exhibited at the "Image and Meaning" conference at the Getty Center in Los Angeles[citation needed].
- 2002: Lecture presentation[citation needed] tensegrity and biological design at Boston Museum of Science.
- 2001: Lecture on tensegrity presented at the "Image and Meaning" conference at MIT in Cambridge, Massachusetts; Tensegrity multimedia presentation included in exhibition "On Growth and Form" at the Textile Museum of Canada in Toronto[citation needed].
References
- ^ Crow, James Mitchell (19 January 2015). "The man who built organs on chips" Archived 2018-07-02 at the Wayback Machine, Cosmos.
- ^ "Donald Ingber", Harvard Medical School.
- ^ "Neomorphics, Inc: Private Company Information". www.bloomberg.com. Retrieved 5 February 2015.
- ^ "Tensegra, Inc.: Private Company Information". www.bloomberg.com. Retrieved 5 February 2015.
- ^ "Emulate Launches to Commercialize Human Organs-on-Chips". www.businesswire.com. 28 July 2014. Retrieved 5 February 2015.
- ^ "Welcome to Opsonix". Opsonix Website. Retrieved 2019-01-10.
- ^ Ingber, Donald (2011). "What We Sort: Venus Paradise Coloring Set", in Sherry Turkle (ed). Falling for Science: Objects in Mind. MIT Press (pp. 252–261), p. 254.
- PMID 24978462.
- ISBN 9780080856889.
- ^ "Engineering Information: Donald Ingber, MD, PhD". www.engineeringdir.com. Retrieved 5 February 2015.
- PMID 2473081.
- ^ "Lab on a Chip Editorial Board Details". www.rsc.org. Retrieved 5 February 2015.
- ^ "Build it Like Mother Nature". wyss.harvard.edu. Archived from the original on 11 February 2015. Retrieved 11 February 2015.
- ^ "Biostasis Project Advances to Next Phase of Development". Wyss Institute. 2020-07-09. Retrieved 2020-07-18.
- ^ "Donald Ingber appointed to Friedrich Merz Guest Professorship at Goethe University". Wyss Institute. 2018-12-05. Retrieved 2020-07-05.
- .
- S2CID 5759959. Retrieved 11 February 2015.
- ^ Ingber DE, Jamieson JD (1985). Cells as tensegrity structures: architectural regulation of histodifferentiation by physical forces transducer over basement membrane (PDF). Orlando: Academic Press. pp. 13–32. Archived from the original (PDF) on 2 February 2015. Retrieved 11 February 2015.
- S2CID 21267494.
- PMID 19083675.
- PMID 7022458.
- ^ "NCI Drug Dictionary". National Cancer Institute.
- S2CID 87206045.
- ^ Phillip, Abby (September 16, 2014). "From E. coli to Ebola: A device that can filter deadly pathogens out of the body", The Washington Post.
- ^ Storr, Krystnell A. (July 5, 2012). "A Shotgun for Blood Clots". Science. Retrieved 11 February 2015.
- ^ S2CID 11951773.
- ^ "Organs-on-Chips". wyss.harvard.edu. Wyss Institute. Archived from the original on 2 February 2015. Retrieved 11 February 2015.
- S2CID 11011310.
- S2CID 206680503.
- ^ Burrell, Teal (August 7, 2013). "Can We Eliminate Animals from Medical Research?". Online Article. PBS. PBS.org. Retrieved 11 February 2015.
- ^ "Harvard's Wyss Institute Creates Living Human Gut-on-a-Chip". wyss.harvard.edu. Wyss Institute. 27 March 2012. Retrieved 11 February 2015.
- ^ "Three 'Organs-on-Chips' ready to serve as disease models, drug testbeds". wyss.harvard.edu. Wyss Institute. Archived from the original on 2 February 2015. Retrieved 11 February 2015.
- ^ "Bone marrow-on-a-chip unveiled". wyss.harvard.edu. Wyss Institute. 28 May 2014. Retrieved 11 February 2015.
- ^ "Taking the brain apart to put it all together again". Wyss Institute. 2018-08-20. Retrieved 2019-01-10.
- ^ "Wyss Institute to Receive up to $37 Million from DARPA to Integrate Multiple Organ-on-Chip Systems to Mimic the Whole Human Body". wyss.harvard.edu. Wyss Institute. 24 July 2012. Retrieved 11 February 2015.
- ^ Drummond, Katie (July 31, 2012). "Military's 'Body-on-a-chip' Could Fast-Track Pharmaceuticals". Online article. Forbes Magazine. Forbes. Retrieved 11 February 2015.
- S2CID 205243157.
- doi:10.1038/487142a.
- PMID 24382894.
- S2CID 691647.
- ^ "Can molecular modeling go quantum?". Wyss Institute. 2018-04-13. Retrieved 2019-01-10.
- ^ "About Us: Wyss Institute". wyss.harvard.edu. Wyss Institute. Archived from the original on 8 February 2015. Retrieved 11 February 2015.
- ISBN 9780309100854. Retrieved 11 February 2015.
- ISBN 0-309-56294-5. Retrieved 11 February 2015.
- ISBN 978-0-309-08639-4. Retrieved 11 February 2015.
- ISBN 9780309096270. Retrieved 11 February 2015.
- ^ https://academic.oup.com/ib/pages/Editorial_Board.
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(help) - ^ "Dr. Donald E. Ingber". NAE Website. Retrieved 2022-05-09.
- ^ "Clarivate Analytics names the world's most impactful scientific researchers with the release of the 2017 Highly Cited Researchers List". Clarivate. 2017-11-15. Retrieved 2019-01-10.
- ^ "2017 Society Award Winners" (PDF). www.biophysics.org. Retrieved 2019-01-10.
- ^ "Ingber receives the 2016 BMES Shu Chien Award". Wyss Institute. 2016-01-08. Retrieved 2019-01-10.
- ^ "Advanced Training Course | Regenerative Medicine at the McGowan Institute". Retrieved 2019-01-10.
- ^ "2016 Tufts Tishler Lectures" (PDF). chem.tufts.edu. Retrieved 2019-01-10.
- ^ "The Leading Global Thinkers of 2015 – Foreign Policy". 2015globalthinkers.foreignpolicy.com. Retrieved 2019-01-10.
- ^ "The 2014 Graeme Clark Oration". www.graemeclarkeoration.org.au. The Graeme Clark Oration. Archived from the original on 3 February 2015. Retrieved 11 February 2015.
- ^ "Watch video recording here". Archived from the original on 2015-02-03.
- ^ "National Center for Advancing Translational Sciences – NCATS Catalyzing Innovation". www.ncats.nih.gov. NCATS.
- ^ "Society of Toxicology honors members for scientific achievements". Press release. EurekAlert! AAAS. Society of Toxicology. February 15, 2013. Retrieved 11 February 2015.
- ^ "Donald Ingber Elected to the Institute of Medicine | Harvard Medical School". hms.harvard.edu. 16 October 2012. Retrieved 2019-01-10.
- ^ "Don Ingber and Wyss Institute Win World Technology Awards". wyss.harvard.edu. Wyss Institute. Archived from the original on 17 February 2013. Retrieved 11 February 2015.
- ^ Mowatt, Twig (February 4, 2011). "Founding Director of Harvard's Wyss Institute Elected to the College of Fellows of the American Institute for Medical and Biological Engineering". Press release. Wyss Institute. Wyss Institute. Retrieved 11 February 2015.
- ^ Mowatt, Twig (December 16, 2011). "Wyss Institute Founding Director Donald Ingber Receives 2011 Holst Medal". Press release. Wyss Institute. Wyss Institute. Retrieved 11 February 2015.
- ^ "Wyss Founding Director Receives Lifetime Achievement Award from the Society of In Vitro Biology". wyss.harvard.edu. Wyss Institute. 7 June 2010. Retrieved 11 February 2015.
- ^ "Wyss Leadership: Donald E. Ingber, M.D., Ph.D." wyss.harvard.edu. Wyss Institute. Archived from the original on 8 February 2015. Retrieved 11 February 2015.
- ^ Weintraub, Karen (October 2, 2009). "Donald Ingber awarded the 2009 BMES Pritzker Distinguished Lectureship for outstanding achievements, originality and leadership". Online article. Harvard Gazette. Harvard Gazette. Retrieved 11 February 2015.
- ^ "Novel noninvasive therapy prevents breast cancer formation in mice". Press release. EurekAlert! AAAS. Wyss Institute. January 1, 2014. Retrieved 11 February 2015.
- ^ "LIFETIME ACHIEVEMENT SYNOPSIS". Marquis Who's Who Ventures LLC. Retrieved 2019-01-10.
- ^ "Art advancing science at the nanoscale". Wyss Institute. 2017-10-18. Retrieved 2019-01-10.
- ^ "Human organs-on-chips named Design of the Year 2015". Wyss Institute. 2015-06-22. Retrieved 2019-01-10.