ESAT-6
| 6 kDa early secretory antigenic target | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | esxA | ||||||
UniProt | P0A564 | ||||||
| |||||||
ESAT-6 or early secreted antigenic target 6 kDa, is produced by
ESAT-6 has been shown to directly bind to the
ESAT-6 is one of the main proteins that is inhibited in the production of vaccines for M. tuberculosis[3][6] with the combination of the increased antigenic factors agβ5-A and the agβ5-C.[6] There are studies that are currently trying to connect the linkage between ESAT-6 and the epithelial cells that are in the lungs, which has shown the dependence on the induction of the IL-8 promoter.[7]
ESAT-6 and CFP-10
There are also connections between the ESAT-6 marker and the CFP-10 marker. These are both being produced in Mycobacterium tuberculosis cells and is subject to the positive correlation of virulence to the amount of protein produced.[8] Recent work shows that the production of these proteins is a process that is caused by the flanking genes.[8][9] ESAT-6 and CFP-10 have also been increasingly used for in house antigen tests that now allow for quick testing of antibodies for the use of TB, but there are still determinations being made on what levels of these antigens or antibiodies would be considered normal.[10]
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See also
References
- ^ "Entrez gene".
- S2CID 22486299.
- ^ PMID 25356553.
- PMID 12379740.
- S2CID 4933280.
- ^ S2CID 17983383.
- PMID 23867456.
- ^ PMID 15973432.
- ^ "DNA Flanking Region - an overview | ScienceDirect Topics". www.sciencedirect.com. Retrieved 2022-05-05.
- ^ "Early Secretory Antigenic Target 6 - an overview | ScienceDirect Topics". www.sciencedirect.com. Retrieved 2022-05-05.