Editas Medicine

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Editas Medicine, Inc.
RevenueDecrease US$19.7 million (2022)
Decrease US$−226 million (2022)
Decrease US$−220 million (2022)
Total assetsDecrease US$514 million (2022)
Total equityDecrease US$361 million (2022)
Number of employees
226 (2023)
Websiteeditasmedicine.com
Footnotes / references
[1]

Editas Medicine, Inc., (formerly Gengine, Inc.), is a clinical-stage biotechnology company which is developing therapies for rare diseases based on CRISPR gene editing technology.[2][3] Editas headquarters is located in Cambridge, Massachusetts and has facilities in Boulder, Colorado.[4][5][6]

History

Editas Medicine was originally founded with the name "Gengine, Inc." in September 2013 by

Flagship Ventures; the name was changed to the current "Editas Medicine" two months later. Doudna quit in June 2014 over legal differences concerning intellectual property of Cas9.[8][9][10]

In August 2015, the company raised $120 million in

Series B funding from Bill Gates and 13 other investors.[11][12] it went public on 2 February 2016,[2] via an initial public offering that raised $94 million.[13][14]

The company entered into a strategic collaboration with

T cell receptor therapeutics to the end of developing cancer therapeutics.[15] Juno was later acquired by Celgene,[16] which was in turn acquired by Bristol Myers Squibb.[17]

The company announced in 2015 that it was planning a clinical trial in 2017 using CRISPR gene editing techniques to treat

FDA gave permission to start the trials, under the investigational name EDIT-101 (also known as AGN-151587).[19][20] In September 2021, a statement from Editas claimed that preliminary results from clinical trials were promising and support clinical benefits of EDIT-101 treatment.[21]

In March 2020, Editas, in partnership with Allergan, was the first to use CRISPR to try to edit DNA inside a person's body (in vivo). As part of the clinical trial, a patient who was nearly blind as a result of Leber's congenital amaurosis received an intravitreal injection containing a harmless virus carrying CRISPR gene-editing instructions.[22][23] Five months later, Editas reworked its deal with Allergan's owner AbbVie and regained full rights to their range of eye disease treatment therapies, including EDIT-101 for the treatment of LCA10.[24]

In 2019, the company was building new chemistry facilities in Boulder, Colorado.[5]

Katrine Bosley was CEO until 2019, when she was replaced by board member Cynthia Collins.[25][26] Collins was replaced in 2021 by James Mullen, who had been board chairman.[27] Gilmore O'Neill, former CMO of Sarepta Therapeutics, became CEO on June 1, 2022, with Mullen staying on as executive chairman of the board.[28]

Research

Editas works with two different CRISPR

nucleases, Cas9 and Cas12a.[29]

EDIT-101 is a CRISPR based gene therapy for treatment of Leber congenital amaurosis, which is currently in clinical trials.

EDIT-301 is an experimental potential treatment utilizing the firm's CAS 12a editing technology for sickle cell disease and beta-thalassemia. In 2019 the firm reported early success in research on the drug;.[30][31] In December 2020, it filed an IND application for treatment of sickle cell disease. In January 2021, it said it had received clearance from the FDA for phase 1 safety studies.[32]

References

  1. ^ "2022 Annual Report (Form 10-K)". U.S. Securities and Exchange Commission. February 22, 2023.
  2. ^
    doi:10.1038/530134a.Open access icon
  3. ^ "Editas Wins FDA Approval for IND of CRISPR Treatment for LCA10". Genetic Engineering & Biotechnology News. 30 November 2018. Retrieved 20 August 2020.
  4. ^ Werley, Jensen (5 September 2019). "How Boulder biotech companies are putting Colorado on the gene-editing map". Denver Business Journal. Retrieved 27 October 2020.
  5. ^ a b Symington, Steve (20 August 2020). "Editas Medicine Remains on Track". The Motley Fool. Retrieved 20 August 2020.
  6. ^ "Who We Are". Editas Medicine. Retrieved 2022-02-25.
  7. ISSN 0099-9660
    . Retrieved 2021-05-27.
  8. ISBN 978-1-9821-1585-2
    .
  9. ^ John Carroll (Nov 25, 2013). "Biotech pioneer in 'gene editing' launches with $43M in VC cash". FierceBiotech.
  10. ^ a b Regalado, Antonio (2015-11-05). "CRISPR Gene Editing to Be Tested on People by 2017, Says Editas". MIT Technology Review. Retrieved 2016-06-21.
  11. ^ Nowogrodzki, Anna (10 August 2015). "Gene-Editing Startup Raises $120 Million to Apply CRISPR to Medicine". MIT Technology Review. Retrieved 12 August 2020.
  12. ^ Loria, Kevin (12 April 2018). "Bill Gates says it would be a 'tragedy' to pass up a controversial, revolutionary gene-editing technology". Business Insider.
  13. ^ Pflanzer, Lydia (2 February 2016). "A Bill Gates-backed startup that wants to edit your genes just raised nearly $100 million". Business Insider.
  14. ^ Fidler, Ben (2 February 2016). "CRISPR Hits Wall Street as Editas Bags $94M in IPO". Xconomy. Retrieved 12 August 2020.
  15. Genetic Engineering & Biotechnology News. 27 May 2015. Retrieved 2016-02-11.Open access icon
  16. ISSN 0099-9660
    . Retrieved 2018-01-22.
  17. ^ Bristol-Myers Squibb Completes Acquisition of Celgene, Creating a Leading Biopharma Company, PM BMS, November 20, 2019; retrieved May 20, 2020
  18. ^ Kuchler, Hannah (6 January 2020). "Crispr puts first human in-body gene editing to test". Financial Times.
  19. PMID 32265555
    .
  20. S2CID 91818387
    . Retrieved 21 December 2018.
  21. ^ "Editas Medicine Announces Positive Initial Clinical Data From Ongoing Phase 1/2 BRILLIANCE Clinical Trial Of EDIT-101 For LCA10". Editas Medicine. 29 September 2021. Archived from the original on 2021-09-29. Retrieved 5 November 2021.
  22. ^ Stein, Rob (4 March 2020). "In A 1st, Scientists Use Revolutionary Gene-Editing Tool To Edit Inside A Patient". NPR. Retrieved 12 August 2020.
  23. ^ Terry, Mark (4 March 2020). "Allergan and Editas Dose First Patient in Historic CRISPR Trial for Inherited Blindness". BioSpace. Retrieved 12 August 2020.
  24. ^ Fidler, Ben (7 August 2020). "Editas, AbbVie rework gene editing deal as pioneering CRISPR trial resumes". BioPharma Dive. Retrieved 12 August 2020.
  25. ^ Dearment, Alaric (22 January 2019). "Editas Medicine CEO steps down as company moves into product development stage". MedCity News. Retrieved 12 August 2020.
  26. ^ DeAngelis, Allison (6 August 2019). "Editas became Cindy Collins. CEO". Boston Business Journal.
  27. ^ "Editas Medicine Announces Appointment Of James C. Mullen As Chief Executive Officer" (Press release). Editas Medicine. 8 February 2021.
  28. ^ Keown, Alex (14 April 2022). "Gilmore O'Neill "Excited" to Take the Reins at Editas Medicine". BioSpace. Retrieved 2 June 2022.
  29. PMID 31147612
    .
  30. ^ Rees, Victoria (20 June 2019). "Experimental treatment for sickle cell disease success". Drug Target Review. Retrieved 20 August 2020.
  31. ^ Wong, Sandi (10 December 2019). "Editas shows better gene editing using Cas9 alternative for sickle cell, thalassemia". BioCentury. Retrieved 20 August 2020.
  32. ^ Carvalho, Joana. "FDA Clears Way for Trial of Gene Editing Therapy for Severe SCD". Retrieved 2021-03-29.
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