Electroneutral cation-Cl
| K-Cl Co-transporter type 1 (KCC1) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | KCl_Cotrans_1 | ||||||||
TCDB | 2.A.30 | ||||||||
| |||||||||
In molecular biology, the electroneutral cation-Cl (electroneutral
.The K-Cl co-transporter (KCC) mediates the coupled movement of
mammalian cells, the net movement is outward.[1]
The neuronal KCC subtype KCC2 is cell-volume insensitive and plays a unique role in maintaining low intracellular Cl−concentration, which is required in
gamma-aminobutyric acid (GABA) and glycine
.
Three
isoform responsible for maintaining low Cl− concentration in neurons.[2][3][4] A study in the model organism C. elegans found that the KCC3 ortholog functions in glial cells to regulate animal behavior.[5]
KCC1 is widely expressed in
splice variants
have also been identified.
KCC3 is widely expressed in human
dysmorphic
features and complete or partial agenesis of the corpus callosum.