F-11,461

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F-11,461
Identifiers
  • 2-[4-[4-[7-(Methoxy-11C)-1-naphthalenyl]-1-piperazinyl]butyl]-4-methyl-1,2,4-triazine-3,5(2H,4H)-dione
JSmol)
  • O=C1C=NN(C(=O)N1C)CCCCN2CCN(C3=CC=CC4=CC=C(O[11C])C=C43)CC2
  • InChI=InChI=1S/C23H29N5O3/c1-25-22(29)17-24-28(23(25)30)11-4-3-10-26-12-14-27(15-13-26)21-7-5-6-18-8-9-19(31-2)16-20(18)21/h5-9,16-17H,3-4,10-15H2,1-2H3/i2-1
  • Key:GKTQBPYMIGXPKG-JVVVGQRLSA-N

F-11,461 is a drug that acts as an agonist of the 5-HT1A receptor (Ki = 1.36 nM) that has been used as a radioligand in PET studies. It possesses modest affinity for the 5-HT7 (Ki = 9.1 nM) and D4 (Ki = 8.5 nM) receptors, although the interaction of F-11,461 with these receptors is not detectable with PET due to their relative scarcity in the brain.[1]

See also

References

  1. PMID 16392798
    .
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