8-OH-DPAT

Source: Wikipedia, the free encyclopedia.
8-OH-DPAT
Kekulé, skeletal formula of 8-OH-DPAT
Names
Systematic IUPAC name
7-(Dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol[1]
Identifiers
3D model (
JSmol
)
Abbreviations 8-OH-DPAT
ChEBI
ChEMBL
ChemSpider
IUPHAR/BPS
MeSH 8-Hydroxy-2-(di-n-propylamino)tetralin
UNII
  • InChI=1S/C16H25NO/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14/h5-7,14,18H,3-4,8-12H2,1-2H3 checkY
    Key: ASXGJMSKWNBENU-UHFFFAOYSA-N checkY
  • InChI=1/C16H25NO/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14/h5-7,14,18H,3-4,8-12H2,1-2H3
    Key: ASXGJMSKWNBENU-UHFFFAOYAY
  • CCCN(CCC)C1CCc2cccc(O)c2C1
  • CCCN(CCC)C1CCC2=C(C1)C(O)=CC=C2
Properties
C16H25NO
Molar mass 247.382 g·mol−1
log P 3.711
Acidity (pKa) 10.539
Basicity (pKb) 3.458
Pharmacology
Pharmacokinetics:
1.5 hours
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
☒N verify (what is checkY☒N ?)

8-OH-DPAT is a

full agonists
to have been discovered.

Originally believed to be selective for the 5-HT1A receptor, 8-OH-DPAT was later found to act as a 5-HT7 receptor agonist and serotonin reuptake inhibitor/releasing agent as well.[2][3][4][5][6]

In animal studies, 8-OH-DPAT has been shown to possess antidepressant,[7] anxiolytic,[8] serenic,[9] anorectic,[10] antiemetic,[11] hypothermic,[12] hypotensive,[13] bradycardic,[13] hyperventilative,[14][15][16] and analgesic effects.[17]

See also

References

  1. ^ "8-hydroxy-2-(di-n-propylamino)tetralin - PubChem Public Chemical Database". The PubChem Project. USA: National Center for Biotechnology Information.
  2. S2CID 39066002
    .
  3. S2CID 41623573
    .
  4. ^ "IUPHAR DATABASE - 5-Hydroxytryptamine receptors - 5-HT7". Archived from the original on 2016-03-03. Retrieved 2009-09-23.
  5. PMID 8922730
    .
  6. S2CID 2984583
    .
  7. PMID 8467355
    .
  8. PMID 7904566
    .
  9. PMID 16310183
    .
  10. S2CID 11047288
    .
  11. PMID 8013549
    .
  12. PMID 1387027
    .
  13. ^
    S2CID 24327371
    .
  14. PMID 10640309
    .
  15. S2CID 224414
    .
  16. S2CID 25951835
    .
  17. PMID 8014862
    .

External links


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