FOLR2
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Folate receptor beta is a protein that in humans is encoded by the FOLR2 gene.[5][6][7]
The protein encoded by this gene is a member of the folate receptor (FOLR) family. Members of this gene family have a high affinity for
folic acid and for several reduced folic acid derivatives, and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. The FOLR2 protein was originally thought to exist only in placenta, but is also detected in spleen, bone marrow, and thymus.[7]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000165457 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032725 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 1133088.
- PMID 7698003.
- ^ a b "Entrez Gene: FOLR2 folate receptor 2 (fetal)".
Further reading
- Henderson GB (1990). "Folate-binding proteins". Annu. Rev. Nutr. 10: 319–35. PMID 2166548.
- Ragoussis J, Senger G, Trowsdale J, Campbell IG (1992). "Genomic organization of the human folate receptor genes on chromosome 11q13". Genomics. 14 (2): 423–30. PMID 1330883.
- Freisheim JH, Price EM, Ratnam M (1990). "Folate coenzyme and antifolate transport proteins in normal and neoplastic cells". Adv. Enzyme Regul. 29: 13–26. PMID 2561247.
- Ratnam M, Marquardt H, Duhring JL, Freisheim JH (1990). "Homologous membrane folate binding proteins in human placenta: cloning and sequence of a cDNA". Biochemistry. 28 (20): 8249–54. PMID 2605182.
- Yan W, Ratnam M (1995). "Preferred sites of glycosylphosphatidylinositol modification in folate receptors and constraints in the primary structure of the hydrophobic portion of the signal". Biochemistry. 34 (44): 14594–600. PMID 7578066.
- Sadasivan E, Cedeno MM, Rothenberg SP (1994). "Characterization of the gene encoding a folate-binding protein expressed in human placenta. Identification of promoter activity in a G-rich SP1 site linked with the tandemly repeated GGAAG motif for the ets encoded GA-binding protein". J. Biol. Chem. 269 (7): 4725–35. PMID 8106441.
- Shen F, Ross JF, Wang X, Ratnam M (1994). "Identification of a novel folate receptor, a truncated receptor, and receptor type beta in hematopoietic cells: cDNA cloning, expression, immunoreactivity, and tissue specificity". Biochemistry. 33 (5): 1209–15. PMID 8110752.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
- Page ST, Owen WC, Price K, Elwood PC (1993). "Expression of the human placental folate receptor transcript is regulated in human tissues. Organization and full nucleotide sequence of the gene". J. Mol. Biol. 229 (4): 1175–83. PMID 8445646.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.
- Wang J, Shen F, Yan W, et al. (1998). "Proteolysis of the carboxyl-terminal GPI signal independent of GPI modification as a mechanism for selective protein secretion". Biochemistry. 36 (47): 14583–92. PMID 9398177.
- Nakashima-Matsushita N, Homma T, Yu S, et al. (1999). "Selective expression of folate receptor beta and its possible role in methotrexate transport in synovial macrophages from patients with rheumatoid arthritis". Arthritis Rheum. 42 (8): 1609–16. PMID 10446858.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMID 12477932.
- Hao H, Qi H, Ratnam M (2003). "Modulation of the folate receptor type beta gene by coordinate actions of retinoic acid receptors at activator Sp1/ets and repressor AP-1 sites". Blood. 101 (11): 4551–60. PMID 12543860.
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