Fatty acid metabolism regulator protein FadR
| FadR C-terminal domain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| |||||||||
In molecular biology, the fatty acid metabolism regulator protein FadR, is a
bacterial transcription factor
.
Bacteria regulate
fatty acid biosynthesis. This single [repressor controls the transcription of the whole fad regulon.[1] Binding of fadR is specifically inhibited by long chain fatty acyl-CoA
compounds.
The
C-terminal domain binds acyl-CoA.[1] The binding of acyl-CoA to the C-terminal domain results in a conformational change that affects the DNA binding affinity of the N-terminal domain.[2]
FadR is a member of the
helical C-terminal domain composed of 6 to 7 alpha helices.[2]