GNPTG

GNPTG
Identifiers
Gene ontology
Molecular function	UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity; protein homodimerization activity;
Cellular component	extracellular region; Golgi membrane; Golgi apparatus; extracellular exosome; membrane; intracellular membrane-bounded organelle;
Biological process	N-glycan processing to lysosome; carbohydrate phosphorylation;
	Sources:Amigo / QuickGO

Ensembl


ENSG00000090581


ENSMUSG00000035521

UniProt


Q9UJJ9


Q6S5C2

RefSeq (mRNA)


NM_032520


NM_172529 NM_001346737

RefSeq (protein)


NP_115909


NP_001333666 NP_766117

Location (UCSC)

Chr 16: 1.35 – 1.37 Mb

Chr 17: 25.45 – 25.46 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

GNPTG (“N-acetylglucosamine-1-phosphate transferase, gamma subunit.”) is a gene in the human body. It is one of three genes that were found to correlate with stuttering.

Function

The GNPTG gene codes instructions for making the gamma subunit of an enzyme called GlcNAc-1-phosphotransferase (also called

mannose-6-phosphate

(M6P). M6P acts as indicator whether a hydrolase should be transported to the lysosome or not. Once a hydrolase has the indication from an M6P, it can be transported to a lysosome.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000090581 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000035521 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000090581 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000035521 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3]

[4]